Abstract
Five strains of Aspergillus fumigatus (A, B, D, H, and K) isolated from sawmills were used to expose groups of three rats by intratracheal intubation. The dose was 10(9) spores per rat. At 48 h after administration, two rats from the D group and all rats from the K group died with symptoms of strong dyspnea and tachypnea. At 72 h postadministration and after, some animals showed mild to moderate dyspnea and tachypnea. Autopsies of all animals were performed, including a histopathological examination of the lungs. At 72 h after administration, two distinct morphological groups were identified histopathologically. Severe necrotizing pneumonia characterized by the presence of abundant fungal hyphae was seen in animals that died spontaneously within 48 h postadministration and rats with bronchopneumonia and was characterized by the presence of numerous fungal spores. There was an obvious difference in pathogenicity among the strains of A. fumigatus. Strains D and K were more pathogenic, and only the rats exposed to these strains showed the presence of fungal hyphae in the lungs. The mycotoxin gliotoxin that is produced by A. fumigatus and has antiphagocytic activity was not detected in the spores from any of the A. fumigatus strains.
References
Jan 7, 1976·Journal of Chromatography·Z DurackováP Nemec
Jul 1, 1985·The Journal of Infectious Diseases·S M Levitz, R D Diamond
Jan 1, 1987·Thorax·M D RobertsonJ A Raeburn
Jun 1, 1987·Thorax·M D RobertsonJ A Raeburn
Sep 1, 1986·The Journal of Infectious Diseases·S M LevitzR D Diamond
Dec 1, 1986·The Journal of Infectious Diseases·R G WashburnJ E Bennett
Apr 1, 1987·Applied and Environmental Microbiology·C J LandH Lundström
Jan 1, 1986·American Journal of Industrial Medicine·G A doPico
Aug 1, 1985·Scandinavian Journal of Work, Environment & Health·P MalmbergG Stålenheim
Jan 1, 1985·Allergy·L Belin
Oct 1, 1967·Journal of Bacteriology·S Ford, L Friedman
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A Müllbacher, R D Eichner
Jan 1, 1984·Immunobiology·V P Kurup
Nov 1, 1984·The Journal of Infectious Diseases·A R WaldorfR D Diamond
May 1, 1981·The Journal of Infectious Diseases·D M WilliamsD J Drutz
Mar 1, 1982·The Journal of Clinical Investigation·A SchaffnerA Braude
Citations
Feb 1, 1994·Mycopathologia·M B FroscoJ D Macmillan
Nov 1, 1993·Mycopathologia·C J LandS Werner
Oct 30, 2009·Critical Reviews in Toxicology·Wijnand Eduard
Aug 21, 2015·Current Allergy and Asthma Reports·Sumit GhoshJane M Schuh
Nov 12, 2013·Environmental Monitoring and Assessment·C ViegasC Veríssimo
Mar 27, 2018·International Journal of Environmental Health Research·Carla ViegasGerard T A Fleming
Jun 1, 2017·Frontiers in Microbiology·Guillaume Desoubeaux, Carolyn Cray