PMID: 18204151Mar 28, 2008Paper

Intratracheally administered corticosteroids improve lung function in meconium-instilled rabbits

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
D MokraAndrea Calkovska

Abstract

Local administration of corticosteroids may diminish acute lung injury associated with meconium aspiration. Budesonide was given intratracheally in 2 doses of 0.25 mg/kg each by means of inpulsion effect of high-frequency jet ventilation 0.5 and 2.5 hours after meconium instillation to oxygen-ventilated adult rabbits. Within 5 hours after the first dose, budesonide significantly improved gas exchange and decreased right-to-left pulmonary shunts, central venous pressure, and ventilatory pressures. In addition, budesonide reduced the meconium-induced lung edema formation, airway hyperreactivity to histamine, count of neutrophils in bronchoalveolar lavage fluid associated with higher total white blood cell and neutrophil counts in the blood, and diminished oxidative modifications of proteins and lipids in lung tissue compared to non-treated meconium-instilled group. The intratracheally administered corticosteroid budesonide effectively improved pulmonary functions and alleviated changes associated with inflammation in meconium-instilled rabbits.

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
D MokraAndrea Calkovska
Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
D MokraAndrea Calkovska
Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
D MokraAndrea Calkovska
© 2021 Meta ULC. All rights reserved