Intratumor chromosomal heterogeneity in advanced carcinomas of the uterine cervix

International Journal of Cancer. Journal International Du Cancer
Heidi LyngPaula M De Angelis

Abstract

Intratumor heterogeneity in chromosomal aberrations is believed to represent a major challenge in the treatment of cancer. The aim of our work was to assess the chromosomal heterogeneity of advanced cervical carcinomas and to distinguish aberrations that had occurred at a late stage of the disease from early events. A total of 55 biopsies, sampled from 2-4 different sites within 20 tumors, were analyzed by use of comparative genomic hybridization. Heterogeneous aberrations were identified as those present in at least 1 of the biopsies and which were not seen, nor seen as a tendency, in the others of the same tumor. The homogeneous aberrations were those seen in all biopsies of the tumor. The most frequent homogeneous aberrations were gain of 3q (65%), 20q (65%) and 5p (50%), indicating that these are early events in the development of the disease. Chromosomal heterogeneity was observed in 11 tumors. The most frequent heterogeneous aberrations were loss of 4p14-q25 (60% of 10 cases with this aberration), and gain of 2p22-pter (50% of 6 cases), 11qcen-q13 (33% of 9 cases) and 8q (27% of 11 cases), suggesting that these events promote progression at a later stage. Many of the heterogeneous regions contained genes known to influenc...Continue Reading

References

May 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A W FylesG A Rawlings
Oct 1, 1994·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A R ChangM E Kirk
Apr 1, 1993·Trends in Genetics : TIG·B Vogelstein, K W Kinzler
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·K HeselmeyerT Ried
Apr 18, 1996·The New England Journal of Medicine·S A Cannistra, J M Niloff
Mar 4, 1997·International Journal of Cancer. Journal International Du Cancer·A HellandR A Lothe
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·S Solinas-ToldoP Lichter
Jan 1, 1999·Nature·C LengauerB Vogelstein
Sep 2, 1999·British Journal of Cancer·P A Lazo
Oct 27, 1999·Genes, Chromosomes & Cancer·A M KersemaekersG J Fleuren
Mar 10, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Z GuoE Wilander
Apr 20, 2001·Cancer Letters·T H CheungY F Wong
Oct 9, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·L T SohK M Hui

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Citations

Apr 9, 2009·Breast Cancer Research and Treatment·Evangelia-Ourania FourkalaMartin Widschwendter
Mar 8, 2011·Clinical & Experimental Metastasis·Teodora Evgenieva GoranovaKikuya Kato
Feb 18, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T SoonthornthumC Verschraegen
Jul 23, 2013·PloS One·Sabrina A H M van den TillaartJan Oosting
Jun 15, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Bruce GottliebMark Trifiro
Sep 24, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lorenz K ThomasMiriam Reuschenbach
Apr 17, 2015·PloS One·Christine HowFei-Fei Liu
Jun 27, 2019·Cells·Patti OlusolaSantanu Dasgupta
Oct 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Barbara BachtiaryFei-Fei Liu

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