PMID: 8584154Dec 1, 1995

Intratumoral chemotherapy

Neurosurgery
K A WalterHenry Brem

Abstract

In an effort to improve survival from malignant gliomas, investigators have used intratumoral chemotherapy protocols to deliver high doses of tumoricidal agents directly to the brain. Theoretically, these infusions bypass the blood-brain barrier, minimize systemic drug levels and the side effects of chemotherapy, and achieve prolonged elevations of intracerebral chemotherapeutic agents relative to those obtainable by systemic administration. Almost all major classes of chemotherapeutic agents have been examined as possible intratumoral therapies via delivery approaches ranging from simple intratumoral injections to implantable computer-driven constant infusion pumps and biodegradable polymer matrices. In this review, we summarize the major clinical trials and experimental investigations underlying the development of intratumoral chemotherapy as a treatment for gliomas.

References

Apr 1, 1976·Journal of Neurology, Neurosurgery, and Psychiatry·T HayakawaH Mogami
Apr 1, 1977·Journal of Neurology, Neurosurgery, and Psychiatry·H A WilkinsonS Weems
Sep 1, 1979·International Journal of Radiation Oncology, Biology, Physics·T S VatsS Tilzer
Feb 1, 1977·Journal of Neurosurgery·J I AusmanJ D Fenstermacher
Feb 1, 1977·Journal of Neurosurgery·C H Tator, W Wassenaar
Dec 1, 1975·Archives of Neurology·V A LevinH D Landahl
Jan 1, 1992·Acta neurochirurgica·G RonquistU Ungerstedt
Jan 1, 1992·Cancer Chemotherapy and Pharmacology·M G DonelliM D'Incalci
May 1, 1990·International Journal of Radiation Oncology, Biology, Physics·B F KimlerT S Vats
Oct 1, 1990·Journal of Neuro-oncology·R J TamargoHenry Brem
Jan 1, 1992·Journal of Neurosurgery·W A Hall, O Fodstad
Feb 1, 1991·Journal of Neuro-oncology·Tadanori Tomita
Sep 28, 1990·Science·R Langer
Sep 1, 1990·Cancer Treatment Reviews·W J ZellerH Stricker
Feb 1, 1989·Journal of Biomedical Materials Research·R J TamargoHenry Brem
Jun 15, 1989·Cancer·M J Wizenberg
Jan 1, 1989·Selective Cancer Therapeutics·Henry BremK W Leong
Jan 1, 1989·Biomaterials, Artificial Cells, and Artificial Organs·S Y LinS H Han
Jan 1, 1988·Annals of the New York Academy of Sciences·P LordR Fischell
Jan 1, 1988·Annals of the New York Academy of Sciences·K T Heruth
Mar 1, 1987·Cancer Treatment Reviews·N H Greig
Jan 1, 1988·Annals of the New York Academy of Sciences·J JohnstonJ Sluetz
Jan 1, 1985·Critical Reviews in Clinical Laboratory Sciences·A A Sandberg
Jan 1, 1986·Journal of Biomedical Materials Research·K W LeongR Langer
Apr 1, 1985·Journal of the Neurological Sciences·A S OliverR O McKeran
Jan 1, 1983·Journal of Neuro-oncology·U Bogdahn
Jun 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·G FirthR O McKeran
Sep 1, 1980·Neurology·F H Hochberg, A Pruitt
Jan 1, 1983·Applied Neurophysiology·R D PennD P Braun
Sep 1, 1982·Journal of Biomedical Materials Research·N UenoL H Liu
Sep 1, 1982·Journal of Pharmaceutical Sciences·A M OmarO M Aboulwafa
Mar 1, 1982·Neurosurgery·J S Kroin, R D Penn
Jan 1, 1981·European Journal of Clinical Pharmacology·F D JumaJ R Trounce
Sep 4, 1995·International Journal of Cancer. Journal International Du Cancer·Jon WeingartHenry Brem
Apr 1, 1995·Journal of Neurosurgery·Jon WeingartHenry Brem
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·M A CahanH Brem
Mar 1, 1994·Journal of Biomedical Materials Research·M P WuR Langer
Jul 1, 1993·Immunology Today·C S Reiss, B T Rouse
Mar 18, 1994·Science·R GrefR Langer
Jul 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·H B HinesR W Wannemacher

Citations

May 18, 1999·International Journal of Cancer. Journal International Du Cancer·C DuvillardB Chauffert
Dec 16, 2006·Journal of Neuro-oncology·H Christopher LawsonHenry Brem
Jun 15, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S NingS J Knox
May 5, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·W VogelhuberA Göpferich
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Brett A AlmondEugene P Goldberg
Oct 22, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mitsunaga KonishiShingo Fujii
Jul 7, 1997·Advanced Drug Delivery Reviews·W Mark Saltzman, L K Fung
Apr 29, 2000·Pharmaceutical Science & Technology Today·J TemsamaniM Kaczorek
Mar 6, 1998·Nature Biotechnology·L H KooleF H van der Veen
Feb 2, 2002·American Journal of Clinical Oncology·Spyridoy VoulgarisHaralabos P Kalofonos
Jun 7, 2000·Current Opinion in Oncology·R I Haroun, Henry Brem
Jan 22, 2003·Neurosurgery·Giuseppe OcchiogrossoMark M Souweidane
May 24, 2012·International Journal of Nanomedicine·Huan XieWilliam T Phillips
Oct 12, 2012·International Journal of Nanomedicine·Xiaolin LiXiaowei Lu
Jun 21, 2002·Clinical Pharmacokinetics·Alison B Fleming, W Mark Saltzman
Apr 23, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Muna AryalNathan McDannold
Aug 24, 2001·Brain Tumor Pathology·T WakabayashiY Kajita
Feb 18, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Stefan MitrasinovicE Sander Connolly
Apr 28, 2005·Expert Review of Neurotherapeutics·Surasak PhuphanichJeffrey J Olson
Oct 13, 2006·Neoplasia : an International Journal for Oncology Research·Twan LammersGert Storm
Jul 26, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Huali ChenQin He
Apr 19, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Lihong ZhangYanyan Jiang
Oct 5, 2010·Critical Reviews in Oncology/hematology·Carlo BuonerbaJohn H Sampson
Aug 17, 2010·Neuroimaging Clinics of North America·Jason M HooverIan F Parney
Apr 29, 2009·Acta Biomaterialia·Wesley N SivakEric J Beckman
Jul 19, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Xiaolin LiBaorui Liu
Apr 15, 2008·International Journal of Pharmaceutics·Ariella ShikanovAbraham J Domb
Apr 1, 2008·Toxicology Letters·E PereverzevaSvetlana E Gelperina
Feb 1, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jong-Ho KimIck Chan Kwon
Aug 19, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·James R WhittleMark A Rosenthal
Feb 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mitsunaga KonishiShingo Fujii
Feb 2, 2012·Chemotherapy Research and Practice·Ariella ShikanovAbraham J Domb
Apr 17, 2007·Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris·C DuvillardB Chauffert
Jul 17, 2015·Advanced Materials·Cassandra E CallmannNathan C Gianneschi
Oct 19, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Laura Saenz del BurgoJose Luis Pedraz
Jun 23, 2012·International Journal of Pharmaceutics·Daniela AllhennAlf Lamprecht
Aug 7, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Guifa XiTadanori Tomita
Mar 1, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Muna AryalNathan McDannold
Feb 19, 2002·The Journal of Pharmacy and Pharmacology·Eugene P GoldbergJames S Marotta
Feb 9, 1999·Medical and Pediatric Oncology·J E Wolff, R M Egeler
Mar 5, 2004·International Journal of Cancer. Journal International Du Cancer·Sebastian C J SteinigerSvetlana E Gelperina
May 7, 2008·Journal of Neuro-oncology·Jeffrey J OlsonJames Stubbs
Apr 18, 2016·Neurosurgical Review·Nancy Ann Oberheim BushMitchel S Berger
Mar 2, 2011·Cancer Biology & Therapy·Hee Dong HanAnil K Sood
Jun 1, 2018·Current Cancer Drug Targets·Xiang ZhangShi-Jie Hu

Related Concepts

Antineoplastic Agents
Brain Tumor, Recurrent
Clinical Trials
Dose-Response Relationship, Drug
Pellet
Mixed Gliomas
Injections, Intralesional
Medication Systems, Programmable Implantable

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