PMID: 11335899May 4, 2001Paper

Intratumoral concentrations of tissue inhibitor of matrix metalloproteinase 1 in patients with gastric carcinoma a new biomartker for invasion and its impact on survival

Cancer
T YoshikawaY Noguchi

Abstract

Previously, the authors clarified that the plasma concentration of tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) in patients with gastric carcinoma was a significant predictor of tumor invasiveness and metastasis. To further clarify the clinical significance of TIMP-1, the authors used an enzyme-linked immunoassay to assess TIMP-1 protein concentrations in samples of tumor tissue from 86 patients who underwent primary resection for gastric carcinoma. Concentrations in samples of normal gastric mucosa from 73 of these patients also were assessed. Tissue TIMP-1 concentrations were significantly greater in gastric tumors than in normal gastric mucosa and were associated significantly with a variety of pathologic factors, including macroscopic type, depth of tumor invasion in the gastric wall, presence of lymphatic vessel invasion, pattern of tumor infiltration into the surrounding tissue, and disease stage. Significantly greater TIMP-1 concentrations were found in tumors that were exposed to the serosal surface compared with tumors that were limited to the submucosal layer. TIMP-1 protein was significantly greater in tumors with lymphatic vessel invasion, an infiltrative pattern into the surrounding tissue (INF-gamma), a...Continue Reading

References

Jun 1, 1984·World Journal of Surgery·S AbeS Suehiro
Jul 1, 1995·World Journal of Surgery·E Tahara
Jul 1, 1995·World Journal of Surgery·P Hermanek, C Wittekind
Jul 1, 1995·World Journal of Surgery·J D Harrison, J W Fielding
Mar 1, 1995·World Journal of Surgery·T IsmailJ W Fielding
Dec 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·W G Stetler-StevensonD E Kleiner
Feb 20, 1996·International Journal of Cancer. Journal International Du Cancer·H NomuraY Okada
Jun 20, 1997·International Journal of Cancer. Journal International Du Cancer·M MoriT Akiyoshi

❮ Previous
Next ❯

Citations

Aug 4, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Eiji MatsumotoYasushi Shiratori
Oct 17, 2002·The Anatomical Record·George E DavisAnil Mavila
Jun 28, 2008·Scandinavian Journal of Gastroenterology·Nanna Møller SørensenNils Brünner
Jan 19, 2018·Oncology Letters·Feng SunWenxian Guan
Mar 16, 2006·British Journal of Cancer·F J G M KubbenH W Verspaget
Jul 10, 2013·Scandinavian Journal of Gastroenterology·Mie GrunnetNils Brünner
Jun 13, 2006·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Takaki YoshikawaYohei Miyagi
Apr 25, 2009·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Takaki YoshikawaOsamu Kobayashi
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Henni RuokolainenTaina Turpeenniemi-Hujanen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.