Intratumoral hemorrhage, vessel density, and the inflammatory reaction contribute to volume increase of sporadic vestibular schwannomas.

Virchows Archiv : an International Journal of Pathology
Maurits de VriesAndel G L van der Mey

Abstract

Vestibular schwannomas show a large variation in growth rate, making prediction and anticipation of tumor growth difficult. More accurate prediction of clinical behavior requires better understanding of tumor biological factors influencing tumor progression. Biological processes like intratumoral hemorrhage, cell proliferation, microvessel density, and inflammation were analyzed in order to determine their role in vestibular schwannoma development. Tumor specimens of 67 patients surgically treated for a histologically proven unilateral vestibular schwannoma were studied. Preoperative magnetic resonance imaging (MRI) scans were used to determine tumor size and to classify tumors as homogeneous, inhomogeneous, and cystic. Immunohistochemical studies evaluated cell proliferation (histone H3 and Ki-67), microvessel density (CD31), and inflammation (CD45 and CD68). Intratumoral hemorrhage was assessed by hemosiderin deposition. The expression patterns of these markers were compared with tumor size, tumor growth index, MRI appearance, patients' age, and duration of symptoms. No relation between cell proliferation and clinical signs of tumor volume increase or MRI appearance was found. Intratumoral hemosiderin, microvessel density, an...Continue Reading

References

Nov 18, 1971·The New England Journal of Medicine·J Folkman
May 1, 1994·The Journal of Laryngology and Otology·S CharabiJ Thomsen
Dec 12, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·K NiemczykF Dubrulle
Feb 15, 2001·The Journal of Laryngology and Otology·P FundováJ Thomsen
Mar 21, 2001·The Journal of Experimental Medicine·E Y LinJ W Pollard
Apr 21, 2001·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·A Gomez-BrouchetB Fraysse
Mar 14, 2002·Journal of Magnetic Resonance Imaging : JMRI·Catherina S P van RijswijkJohan L Bloem
Jul 27, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P B VermeulenL Y Dirix
Jan 9, 2004·Acta Oto-laryngologica·Jürgen BriegerWolf J Mann
Aug 26, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Hiroyuki TakahashiYasuo Takano
Oct 19, 2006·Journal of Neurosurgery·Chul-Kee ParkHee-Won Jung
Aug 28, 2007·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Dimitrios KoutsimpelasJuergen Brieger
Feb 16, 2008·Lancet·Alberto MantovaniFrancesco M Marincola
Mar 11, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Sumit Sinha, B S Sharma
Mar 12, 2008·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Stephen E M JonesDavid A Moffat
Aug 2, 2008·Journal of Neurosurgery·Andreas StadlbauerOliver Ganslandt
Apr 30, 2009·Cancer·Ivan PedrosaNeil M Rofsky
May 27, 2009·Carcinogenesis·Francesco ColottaAlberto Mantovani
Sep 11, 2009·Journal of Leukocyte Biology·G SolinasP Allavena
Dec 19, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laureen S OjalvoJeffrey W Pollard
Dec 22, 2010·Expert Review of Molecular Diagnostics·Rita A MukhtarLaura J Esserman
Mar 5, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emilie P BuddinghAnne-Marie Cleton-Jansen
Nov 26, 2011·Virchows Archiv : an International Journal of Pathology·Carlos E de AndreaPancras C W Hogendoorn

❮ Previous
Next ❯

Citations

Dec 12, 2012·Virchows Archiv : an International Journal of Pathology·Maurits de VriesPancras C W Hogendoorn
Jan 24, 2014·Brain Pathology·David A Hilton, Clemens Oliver Hanemann
Jun 8, 2015·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Maurits de VriesPancras C W Hogendoorn
May 30, 2016·Acta Neuropathologica·Alexander SchulzHelen Morrison
Sep 23, 2016·AJR. American Journal of Roentgenology·Kanae K MiyakeKaori Togashi
Oct 6, 2016·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Neil S PatelMatthew L Carlson
Jun 19, 2013·Surgical Neurology International·Giuseppe MaimoneCambria Mauro
Feb 7, 2018·The Laryngoscope·Samuel MacKeithJames R Tysome
Apr 30, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jose M Anton-RodriguezJulian C Matthews
Dec 24, 2018·Virchows Archiv : an International Journal of Pathology·W M de VriesP C W Hogendoorn
Apr 25, 2019·NMC Case Report Journal·Masaaki KubotaYoshinori Higuchi
Jun 25, 2020·Journal of Medical Genetics·Katherine V SadlerD Gareth Evans
Mar 11, 2020·Acta neurochirurgica·Johannes WachErdem Güresir
Jul 10, 2020·Neuro-oncology Advances·Cathal John HannanOmar Nathan Pathmanaban
Jul 4, 2020·Oncogene·Dario-Lucas HelbingHelen Morrison
Oct 5, 2019·Pathology, Research and Practice·Gino MarioniElisabetta Zanoletti
Jan 26, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Patrick P J H LangenhuizenJeroen B Verheul
Jan 26, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Wenya Linda BiIan F Dunn
Jul 11, 2021·European Journal of Medical Research·Jiang HuajunYang Jingjing

❮ Previous
Next ❯

Software Mentioned

ImageJ
Mirax

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.