Abstract
Dedicated breast positron emission tomography (DbPET) provides detailed high-resolution images and can detect intratumoral heterogeneity using 18F-fluorodeoxyglucose (FDG). We aimed to evaluate the correlation between FDG uptake on DbPET and the clinicopathological features of breast cancer, particularly those with an intratumoral heterogeneous distribution of FDG on DbPET. We evaluated 195 consecutive patients with invasive breast cancer who underwent preoperative whole-body PET (WBPET) and DbPET concurrently between January 2016 and March 2017. The relationships between clinicopathological factors and the maximum standard uptake values (SUVmax) of DbPET and WBPET, including clinical stage, nuclear grade, Ki67 proliferation index, estrogen receptor (ER) and human epidermal growth factor receptor type 2 (HER2) statuses, and the intratumoral heterogeneous distribution of FDG on DbPET, were evaluated. The SUVmax of DbPET was significantly correlated with clinical T stage, N stage, nuclear grade, and Ki67 proliferation index (all p < 0.001) as well as the ER (p = 0.006) and HER2 (p = 0.040) statuses. Intratumoral heterogeneous distribution of FDG on DbPET was significantly related with high nuclear grade (p = 0.016) and high Ki67 ...Continue Reading
References
Nov 18, 1998·European Journal of Nuclear Medicine·F CrippaE Bombardieri
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J F VansteenkisteM G Demedts
Feb 27, 2001·The American Journal of Surgical Pathology·R E JimenezD W Visscher
Jan 12, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Reinhard BosCarla F M Molthoff
Sep 25, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Andreas BuckTorsten Mattfeldt
Mar 24, 2006·Breast Cancer Research and Treatment·Rakesh KumarAbass Alavi
Jun 21, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Alina Berriolo-RiedingerFrançois Brunotte
Jan 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Thierry BerghmansUNKNOWN European Lung Cancer Working Party for the IASLC Lung Cancer Staging Project
Aug 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David FusterFrancesca Pons
Dec 17, 2009·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Julia TchouMitchell Schnall
Aug 19, 2010·Histopathology·Lin YuHongfen Lu
Nov 9, 2010·European Journal of Nuclear Medicine and Molecular Imaging·David GroheuxElif Hindié
Apr 22, 2011·Diagnostic Pathology·S FasanellaM Barbareschi
Apr 14, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·O HumbertF Brunotte
Aug 31, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mami IimaKaori Togashi
Dec 18, 2012·Journal of the National Cancer Institute·David GroheuxMarc Espié
Mar 19, 2013·Breast Cancer Research and Treatment·Jessica Anna CintoloDaniel A Pryma
Sep 13, 2013·Breast Cancer Research and Treatment·Takayuki KadoyaMorihito Okada
Jan 18, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Amy M Fowler
May 3, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Feifei NaYou Lu
May 9, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kanae K MiyakeKaori Togashi
May 21, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·David GroheuxMarc Espié
Jun 1, 2014·Annals of Nuclear Medicine·Makoto HosonoYukihiko Ozawa
Feb 24, 2015·Breast Cancer Research and Treatment·Kenjiro AogiMorihito Okada
May 6, 2016·Medical Physics·Trinitat García HernándezMaria Del Puig Cozar Santiago
Jun 7, 2017·European Journal of Radiology·Kayo NishimatsuKaori Togashi
Feb 6, 2018·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Shinsuke SasadaMorihito Okada
Citations
Jul 4, 2019·Breast Cancer Research and Treatment·Shinsuke SasadaMorihito Okada
Mar 15, 2019·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Kayo FukuiMorihito Okada
May 23, 2019·Annals of Nuclear Medicine·Rena SakaguchiKaori Togashi
Mar 27, 2021·Physics in Medicine and Biology·Abhijit J Chaudhari, Ramsey D Badawi
Aug 8, 2021·Diagnostics·Kanae K MiyakeYuji Nakamoto
Jan 11, 2022·Clinical Nuclear Medicine·Shinsuke SasadaTakayuki Kadoya