Intratumoral heterogeneity on dedicated breast positron emission tomography predicts malignancy grade of breast cancer

Breast Cancer Research and Treatment
Norio MasumotoMorihito Okada

Abstract

Dedicated breast positron emission tomography (DbPET) provides detailed high-resolution images and can detect intratumoral heterogeneity using 18F-fluorodeoxyglucose (FDG). We aimed to evaluate the correlation between FDG uptake on DbPET and the clinicopathological features of breast cancer, particularly those with an intratumoral heterogeneous distribution of FDG on DbPET. We evaluated 195 consecutive patients with invasive breast cancer who underwent preoperative whole-body PET (WBPET) and DbPET concurrently between January 2016 and March 2017. The relationships between clinicopathological factors and the maximum standard uptake values (SUVmax) of DbPET and WBPET, including clinical stage, nuclear grade, Ki67 proliferation index, estrogen receptor (ER) and human epidermal growth factor receptor type 2 (HER2) statuses, and the intratumoral heterogeneous distribution of FDG on DbPET, were evaluated. The SUVmax of DbPET was significantly correlated with clinical T stage, N stage, nuclear grade, and Ki67 proliferation index (all p < 0.001) as well as the ER (p = 0.006) and HER2 (p = 0.040) statuses. Intratumoral heterogeneous distribution of FDG on DbPET was significantly related with high nuclear grade (p = 0.016) and high Ki67 ...Continue Reading

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Citations

Jul 4, 2019·Breast Cancer Research and Treatment·Shinsuke SasadaMorihito Okada
Mar 15, 2019·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Kayo FukuiMorihito Okada
Mar 27, 2021·Physics in Medicine and Biology·Abhijit J Chaudhari, Ramsey D Badawi
Jan 11, 2022·Clinical Nuclear Medicine·Shinsuke SasadaTakayuki Kadoya

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