Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNgamma-transduced tumor cell immunotherapy of experimental glioma

Journal of Neuroimmunology
Salina GunnarssonJohan Bengzon

Abstract

The present study reports regression of pre-established experimental rat gliomas as a result of combining peripheral immunization using interferon gamma (IFNgamma) transduced autologous tumor cells with local intratumoral delivery of interleukin 7 (IL-7) by mesenchymal stromal cells. IL-7 alone significantly decreased the tumor area and this effect was enhanced with IFNgamma immunization. A higher density of intratumoral T-cells was observed in animals receiving combined therapies compared to rats receiving either cytokine alone suggesting that the therapeutic effect is dependent on a T-cell response.

References

May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T AokiT Honjo
Jul 1, 1993·Cancer Immunology, Immunotherapy : CII·P SiesjöH O Sjögren
May 16, 2002·Blood·Terry J Fry, Crystal L Mackall
Sep 29, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans Herbert SteinerChristel Herold-Mende
Feb 27, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Betty LiKarin Jooss
Sep 5, 2007·Cytokine·Christina Kittipatarin, Annette R Khaled
Nov 6, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Daniel BexellJohan Bengzon
Mar 18, 2009·International Journal of Cancer. Journal International Du Cancer·Daniel BexellAnna Darabi

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Citations

Mar 16, 2012·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Margaret F BennewitzErik M Shapiro
Apr 22, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Daniel BexellJohan Bengzon
May 28, 2013·Molekuliarnaia biologiia·S Sh KarshievaA V Beliavskiĭ
Aug 27, 2013·Endocrine-related Cancer·W Nathaniel BrennenJohn T Isaacs
Jul 26, 2013·Therapeutic Delivery·Alicia Sawdon, Ching-An Peng
Nov 10, 2010·Expert Opinion on Biological Therapy·Timothy J MyersAnna Spagnoli
Mar 20, 2013·Biomatter·Marta CompteLuís Alvarez-Vallina
Dec 20, 2011·World Journal of Stem Cells·Xu-Yong SunLong-Jun Dai
May 6, 2015·Acta Medica (Hradec Králové)·Petr KrůpaStanislav Filip
Aug 10, 2010·The Cancer Journal·Natasha M Fewkes, Crystal L Mackall
Jul 19, 2013·The Korean Journal of Internal Medicine·Nayoun Kim, Seok-Goo Cho
Nov 10, 2013·Cancers·Aneta KwiatkowskaMariano S Viapiano
May 13, 2018·International Journal of Cancer. Journal International Du Cancer·Francesca Romana StefaniJohan Bengzon
Jul 22, 2018·Neural Regeneration Research·Chang-Geng SongHua Han
Feb 13, 2016·Oncology Letters·Hiroki NambaTomohiro Yamasaki
May 20, 2021·CNS Oncology·Anda-Alexandra CalinescuSue K O'Shea
Jul 16, 2011·Molecular Pharmaceutics·Marina CihovaCestmir Altaner

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