Intratumoral immune cells expressing PD-1/PD-L1 and their prognostic implications in cancer: a meta-analysis

The International Journal of Biological Markers
Younghoon KimGyeong Hoon Kang

Abstract

The prognostic value of immune cells expressing programmed cell death 1 (PD-1) and PD-1 ligand 1 (PD-L1) in cancer are controversial, and the potential differential impact of using tissue microarrays and whole tissue sections to assess the positivity of immune cells has not been addressed. The current study included 30 eligible studies with 7251 patients that evaluated the relationship between tumor-infiltrating lymphocytes expressing PD-1/PD-L1 and overall survival and disease-free survival, or progression-free survival. Subgroup analysis was based on the tissue type of cancer and the type of tissue sampling (tissue microarray or whole tissue section). In the meta-analysis, PD-1-positive and PD-L1-positive tumor-infiltrating lymphocytes had a positive effect on disease-free survival or progression-free survival (hazard ratio [HR] 0.732; 95% confidence interval [CI] 0.565, 0.947; and HR 0.727; 95% CI 0.584, 0.905, respectively). PD-L1-positive tumor-infiltrating lymphocytes had a positive impact on overall survival in studies using tissue microarray (HR 0.586; 95% CI 0.476, 0.721), but had a poor impact when only whole tissue sections were considered (HR 1.558; 95% CI 1.232, 1.969). Lung cancer was associated with good overall ...Continue Reading

References

Mar 21, 2001·Human Molecular Genetics·O P KallioniemiG Sauter
Aug 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephen A BoorjianIgor Frank
Feb 12, 2014·Cancer Immunology, Immunotherapy : CII·Shenyou SunKunwei Shen
Sep 7, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T K ChoueiriS Signoretti
Jan 21, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J BellmuntS Signoretti
Feb 11, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Moon-Young KimDoo Hyun Chung
Jun 28, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Fei ZhouCaicun Zhou
Jul 18, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jaemoon KohDoo Hyun Chung
Aug 28, 2015·PloS One·Lars Henning SchmidtWolfgang Hartmann
Feb 24, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ching-Yao YangPan-Chyr Yang
Mar 25, 2016·Oncotarget·Christine BögerChristoph Röcken
Apr 26, 2016·Journal of Surgical Oncology·Takashi MukaigawaSatoshi Fujii
Jun 3, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Edwin R ParraIgnacio I Wistuba
Jul 1, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julien CalderaroJean-Michel Pawlotsky
Oct 28, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lik Hang LeeJinru Shia
Aug 27, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marius IliePaul Hofman
Sep 16, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Akihito KawazoeAtsushi Ochiai
Oct 28, 2016·OncoTargets and Therapy·Yangwei FanYinying Wu
Dec 3, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Brant A InmanMichael R Harrison
Nov 18, 2017·Annals of Diagnostic Pathology·Archana George VallonthaielDeepali Jain

❮ Previous
Next ❯

Citations

Sep 8, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Paul BuderathThomas Hager

❮ Previous
Next ❯

Software Mentioned

Engauge Digitizer
Comprehensive meta - analysis

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.