Intratumoral Injection of HSV1716, an Oncolytic Herpes Virus, Is Safe and Shows Evidence of Immune Response and Viral Replication in Young Cancer Patients

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Keri A StrebyTimothy P Cripe

Abstract

Purpose: HSV1716 is an oncolytic herpes simplex virus-1 (HSV-1) studied in adults via injection into the brain and superficial tumors. To determine the safety of administering HSV1716 to pediatric patients with cancer, we conducted a phase I trial of image-guided injection in young patients with relapsed or refractory extracranial cancers.Experimental Design: We delivered a single dose of 105 to 107 infectious units of HSV1716 via computed tomography-guided intratumoral injection and measured tumor responses by imaging. Patients were eligible for up to three more doses if they achieved stable disease. We monitored HSV-1 serum titers and shedding by PCR and culture.Results: We administered a single dose of HSV1716 to eight patients and two doses to one patient. We did not observe any dose-limiting toxicities. Adverse events attributed to virus included low-grade fever, chills, and mild cytopenias. Six of eight HSV-1 seronegative patients at baseline showed seroconversion on day 28. Six of nine patients had detectable HSV-1 genomes by PCR in peripheral blood appearing on day +4 consistent with de novo virus replication. Two patients had transient focal increases in metabolic activity on 18fluorine-deoxyglucose PET, consistent wit...Continue Reading

References

Jul 1, 1988·The Journal of General Virology·D J McGeochP Taylor
Sep 10, 2002·Journal of Pediatric Hematology/oncology·Neeti S BharatanTimothy P Cripe
Dec 23, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Timothy P CripeCaroline J Breitbach
May 28, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert H I AndtbackaRobert S Coffin
Jun 15, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Igor PuzanovRobert H I Andtbacka

❮ Previous
Next ❯

Citations

Mar 6, 2018·The Journal of Clinical Investigation·Dmitriy ZamarinJedd D Wolchok
Mar 29, 2019·Cancer Gene Therapy·Joshua D BernstockGregory K Friedman
Dec 13, 2019·Cancer Metastasis Reviews·Brian HutzenTimothy P Cripe
May 30, 2019·Nature Communications·Naiara Martínez-VélezMarta M Alonso
Oct 31, 2019·Microbiology and Immunology·Maria TerrívelAna Miguel Matos
Dec 14, 2018·Oncoimmunology·Jonathan G PolLorenzo Galluzzi
Feb 23, 2020·Human Vaccines & Immunotherapeutics·Moumita MondalDongming Zhou
Feb 8, 2020·Journal of Cellular Physiology·Hanwen LiXiawei Wei
Feb 23, 2019·Infectious Agents and Cancer·Alberto RealeGiorgio Palù
Jun 28, 2018·Paediatric Drugs·Mary Frances WedekindTimothy P Cripe
Jul 11, 2018·Cancers·Maider Varela-GuruceagaMarta M Alonso
May 7, 2020·Frontiers in Oncology·Lizhi LiJian Ma
Oct 6, 2020·Frontiers in Oncology·Guo-Dong CaoMao-Ming Xiong
Oct 14, 2020·EMBO Molecular Medicine·Thomas Gp GrünewaldDominique Heymann
Oct 23, 2020·International Journal of Molecular Sciences·Chang-Myung OhChan Kim
Dec 10, 2020·Journal for Immunotherapy of Cancer·Erin MoralesDjordje Atanackovic
Nov 8, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sarah J DansonPenella J Woll
Oct 28, 2019·Molecular Therapy Oncolytics·Brian HutzenKevin A Cassady
Dec 29, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ke-Tao JinShi-Bing Wang
Nov 2, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Norihiro WatanabeMasataka Suzuki
Nov 11, 2020·International Journal of Molecular Sciences·Laura Menotti, Elisa Avitabile
Feb 3, 2021·Journal for Immunotherapy of Cancer·Harsimrat Kaur BirdiMichele Ardolino
Dec 17, 2020·Cancers·Oleg MozheiSergey Kasparov
Dec 11, 2020·Molecular Cancer Therapeutics·Amy KwanMunitta Muthana
Oct 16, 2020·International Journal of Molecular Sciences·Mary Cook, Aman Chauhan
Feb 14, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·David RuanoManuel Ramírez
Apr 25, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chen YangXiangmin Tong
Mar 20, 2021·Journal of Medical Virology·Weijian LinLiping Zhong
Apr 28, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Noraini Abd-Aziz, Chit Laa Poh
Jun 8, 2021·Virology : Research and Treatment·Prapti H ModyJuliet V Spencer
Jul 3, 2021·Cells·Norah AldrakNada Zaidan
Jun 19, 2021·Frontiers in Oncology·Thijs A van SchaikKhalid Shah

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.