Intratumoral polymorphonuclear granulocyte is associated with poor prognosis in squamous esophageal cancer by promoting epithelial-mesenchymal transition

Future Oncology
Pingping HuQi Liu

Abstract

The role of polymorphonuclear granulocyte (PMN) infiltration in tumor remains unclear in esophageal cancer (EC). We conducted a retrospective study on consecutive patients with primary squamous EC. The potential roles of PMN infiltration into tumor nests were assessed by immunohistochemistry. The interactions of PMNs and tumor cells were investigated in an in vitro coculture system. Intratumoral PMN is an independent prognostic factor. PMN infiltration induces epithelial-mesenchymal transition of cancer cells with the initiation of TGF-β/Smad signaling pathway. Our study demonstrates intratumoral PMN is an independent unfavorable predictor in squamous EC. PMN promotes cancer progression partly by its ability to induce epithelial-mesenchymal transition via TGF-β/Smad signaling pathway.

References

Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·Y ShoenfeldJ Pinkhas
Nov 20, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Véronique MassonAgnès Noël
Oct 1, 2010·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hanna Bessler, Meir Djaldetti
Nov 26, 2010·Immunity·Niels Borregaard
Dec 31, 2010·International Journal of Cancer. Journal International Du Cancer·Sokratis TrellakisSven Brandau
Feb 18, 2011·International Journal of Cancer. Journal International Du Cancer·Simon TazzymanCraig Murdoch
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jul 30, 2011·Critical Reviews in Oncology/hematology·H PiccardG Opdenakker
May 26, 2012·Seminars in Cancer Biology·Jonas Fuxe, Mikael C I Karlsson
Dec 1, 2012·Current Opinion in Oncology·Yoko KatsunoRik Derynck
Mar 5, 2013·Seminars in Cancer Biology·Sven Brandau
Mar 12, 2013·Cancer Letters·Chevaun D MorrisonWilliam P Schiemann
Feb 22, 2014·Nature Reviews. Molecular Cell Biology·Samy LamouilleRik Derynck

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Citations

Jan 30, 2019·Future Oncology·Pingping HuJiandong Zhang
Jul 3, 2021·Cancers·Rogelio González-GonzálezRonell Bologna-Molina
Sep 2, 2021·Experimental and Therapeutic Medicine·Laura MaziluSerban-Mircea Negru

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