Intratumorally Establishing Type 2 Innate Lymphoid Cells Blocks Tumor Growth

The Journal of Immunology : Official Journal of the American Association of Immunologists
Juyang KimByungsuk Kwon

Abstract

A long-standing question in the field of tumor immunotherapy is how Th2 cytokines block tumor growth. Their antitumor effects are particularly prominent when they are secreted continuously in tumors, suggesting that Th2 cytokines may create a tumor microenvironment unfavorable for tumor growth independently of adaptive immunity. In this study, we show that local production of IL-33 establishes a high number of type 2 innate lymphoid cells (ILC2s) with potent antitumor activity. IL-33 promotes secretion of a massive amount of CXCR2 ligands from ILC2s but creates a tumor microenvironment where tumor cells express CXCR2 through a dysfunctional angiogenesis/hypoxia/reactive oxygen species axis. These two signaling events converge to reinforce tumor cell-specific apoptosis through CXCR2. Our results identify a previously unrecognized antitumor therapeutic pathway wherein ILC2s play a central role.

References

Feb 1, 1994·Human Gene Therapy·R I Tepper, J J Mulé
Apr 1, 1993·European Journal of Immunology·S Krüger-KrasagakesT Blankenstein
Jun 9, 2004·International Immunology·Hak-Ling MaKyriaki Dunussi-Joannopoulos
Sep 16, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander ZarbockKlaus Ley
Jan 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew L RankinStefan Pflanz
Jan 19, 2010·Nature Reviews. Immunology·Foo Y LiewIain B McInnes
Mar 5, 2010·Nature·Daniel R NeillAndrew N J McKenzie
Oct 5, 2010·Journal of Immunological Methods·Wonyoung KimByungsuk Kwon
Jul 19, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julie M RodaTimothy D Eubank
Aug 16, 2011·Developmental Cell·Annika ArmulikChrister Betsholtz
Sep 3, 2011·European Journal of Immunology·Qianting YangBinfeng Lu
Jan 17, 2012·Trends in Cell Biology·Juan Carlos Acosta, Jesús Gil
Feb 11, 2012·Science·Weldy V BonillaDaniel D Pinschewer
Jun 5, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hongnga T LeByungsuk Kwon
Jan 26, 2013·Nature Reviews. Immunology·Hergen SpitsEric Vivier
Feb 20, 2013·The Journal of Experimental Medicine·Ari B MolofskyRichard M Locksley
Apr 27, 2013·Science·Amanda M JamiesonRuslan Medzhitov
May 21, 2013·Nature Immunology·Paula Licona-LimónRichard A Flavell
Jan 1, 2011·Cancers·Sylvia Lee, Kim Margolin
Jan 23, 2014·Cancer Research·Daniel O VillarrealDavid B Weiner
Nov 28, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xin GaoBinfeng Lu

❮ Previous
Next ❯

Citations

Jun 25, 2016·Immune Network·Sang Jun ParkByungsuk Kwon
Oct 31, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alan LongBin Zhang
Nov 12, 2019·International Journal of Cancer. Journal International Du Cancer·Lu QiFang Fang
May 16, 2018·World Journal of Gastroenterology : WJG·Yue ShenWei Jiang
Feb 23, 2020·Nature·John Alec MoralVinod P Balachandran
Nov 30, 2018·Frontiers in Immunology·Claudia AfferniGiovanna Schiavoni
Apr 27, 2019·Frontiers in Immunology·Melanie Bruchard, Francois Ghiringhelli
Jul 30, 2019·Frontiers in Immunology·Jia XiongQingqing Wang
Jun 27, 2019·Immunotherapy·Shunfeng Hu, Xin Wang
Dec 19, 2019·Frontiers in Immunology·Giuseppe ErcolanoCamilla Jandus
Feb 18, 2020·Frontiers in Immunology·Nicola TuminoLorenzo Moretta
Sep 21, 2017·Nature Communications·Sara TrabanelliCamilla Jandus
Sep 5, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Camille Guillerey
Oct 19, 2019·Journal of Cellular Physiology·Jie WanHuaxi Xu
Oct 3, 2018·Cellular & Molecular Immunology·Ning LiuSiqing Wang
Nov 13, 2018·Frontiers in Immunology·Jean-Jacques Fournié, Mary Poupot
Nov 4, 2020·Cancers·Aintzane ApraizBeatriz Arteta
Aug 18, 2020·Molecular Aspects of Medicine·Simona SivoriLorenzo Moretta
Dec 18, 2020·Frontiers in Immunology·Sara AndreoneFabrizio Mattei
Nov 26, 2020·Cancers·Enrico MaggiFrancesco Annunziato
Feb 27, 2020·Cell Reports·Marek WagnerShigeo Koyasu
Apr 1, 2020·Trends in Immunology·Sophie Guia, Emilie Narni-Mancinelli
Jun 9, 2021·Nature Immunology·Melanie Bruchard, Francois Ghiringhelli
Jun 17, 2021·European Journal of Immunology·Wenyi JiangYi Zhang
Jun 18, 2021·Frontiers in Immunology·Simon SchreiberSascha Kahlfuss
Apr 9, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xingyuan XuTingbo Liang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.