Intratumour microbiome associated with the infiltration of cytotoxic CD8+ T cells and patient survival in cutaneous melanoma.

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Gongjian ZhuLingeng Lu

Abstract

The gut microbiome plays an important role in systemic inflammation and immune response. Microbes can translocate and reside in tumour niches. However, it is unclear how the intratumour microbiome affects immunity in human cancer. The purpose of this study was to investigate the association between intratumour bacteria, infiltrating CD8+ T cells and patient survival in cutaneous melanoma. Using The Cancer Genome Altas's cutaneous melanoma RNA sequencing data, levels of intratumour bacteria and infiltrating CD8+ T cells were determined. Correlation between intratumour bacteria and infiltrating CD8+ T cells or chemokine gene expression and survival analysis of infiltrating CD8+ T cells and Lachnoclostridium in cutaneous melanoma were performed. Patients with low levels of CD8+ T cells have significantly shorter survival than those with high levels. The adjusted hazard ratio was 1.57 (low vs high) (95% confidence interval: 1.17-2.10, p = 0.002). Intratumour bacteria of the Lachnoclostridium genus ranked top in a positive association with infiltrating CD8+ T cells (correlation coefficient = 0.38, p = 9.4 × 10-14), followed by Gelidibacter (0.31, p = 1.13 × 10-9), Flammeovirga (0.29, p = 1.96 × 10-8) and Acinetobacter (0.28, p = 8.9...Continue Reading

References

Jun 2, 2005·Nature Reviews. Immunology·Foo Y LiewLuke A J O'Neill
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jun 7, 2011·The New England Journal of Medicine·Caroline RobertJedd D Wolchok
Dec 14, 2011·Cell·Maria HatziapostolouDimitrios Iliopoulos
Mar 4, 2014·Genome Biology·Derrick E Wood, Steven L Salzberg
Apr 1, 2014·Cell·Yasmine Belkaid, Timothy W Hand
Jul 30, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sylvia AdamsSunil S Badve
Mar 20, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Harriet M KlugerLucia B Jilaveanu
Apr 23, 2015·Nature·Sebastian KreiterUgur Sahin
Sep 12, 2015·Science·Eliezer M Van AllenLevi A Garraway
Jan 24, 2017·Cell·Matthew H SpitzerEdgar G Engleman
Apr 4, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ChaputF Carbonnel
May 18, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ricardo E VilainRichard A Scolyer
Jul 6, 2017·Nature·Patrick A OttCatherine J Wu
Feb 14, 2018·Gut·Eleonora CremonesiGiandomenica Iezzi
Mar 31, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jarem EdwardsUmaimainthan Palendira
Apr 11, 2018·Cancer Cell·Vancheswaran GopalakrishnanJennifer A Wargo
Sep 5, 2018·Methods in Molecular Biology·Lulu FarhanaAdhip P N Majumdar
May 16, 2019·Cancer Immunology Research·Joseph CursonsMelissa J Davis
Mar 10, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A AlgaziA I Daud
Nov 8, 2020·Nature Communications·Francisco Avila CobosKatleen De Preter

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Citations

Jul 3, 2021·World Journal of Microbiology & Biotechnology·Weitao ShenRan Liu
Nov 7, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A W MaoH Chang

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