PMID: 11910622Mar 26, 2002Paper

Intrauterine application of progestins in hormone replacement therapy: a review

Climacteric : the Journal of the International Menopause Society
F E Riphagen

Abstract

The intrauterine application of progestins as endometrial protection against hyperstimulation by estrogen replacement therapy has been investigated in clinical trials since the early 1990s and one product has become available for this indication. This review considers the available published and presented reports on intrauterine use of progestin to date. Reports of 19 studies were reviewed. These studies included both peri- and postmenopausal women (826 in total), treated with different types of estrogens administered via various routes. Progesterone was used in two small studies, while all other studies used different doses of levonorgestrel for periods ranging from 6 months to more than 5 years. Endometrial effects, bleeding profiles, systemic effects (symptoms and metabolic), as well as clinical experience, were considered and were comparable to other forms of continuous combined hormone replacement therapy (HRT). It is concluded that the current evidence supports complete endometrial protection and a good safety profile. The observed bleeding profiles appear favorable but have not yet been directly compared with other forms of continuous combined HRT. A favorable effect on serum lipids has been observed and also awaits dire...Continue Reading

References

Aug 1, 1992·The Journal of Clinical Endocrinology and Metabolism·F PekonenE M Rutanen
Dec 19, 1991·The New England Journal of Medicine·D ShoupeR A Lobo
Dec 1, 1986·Fertility and Sterility·R J King, M I Whitehead
Feb 1, 1986·American Journal of Obstetrics and Gynecology·W E GibbonsD R Mishell
Oct 1, 1988·British Journal of Obstetrics and Gynaecology·T SporrongL A Mattsson
Jun 1, 1986·Fertility and Sterility·C G NilssonD N Robertson
Jan 1, 1986·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·S G SilverbergT Luukkainen
Dec 31, 1981·The New England Journal of Medicine·M I WhiteheadR J King
Mar 1, 1995·Clinical Pharmacokinetics·K Fotherby
Feb 1, 1995·American Journal of Obstetrics and Gynecology·S P SuhonenP Lähteenmäki
Jan 1, 1993·Baillière's Clinical Endocrinology and Metabolism·M S Marsh, M I Whitehead
Feb 1, 1997·Acta Obstetricia Et Gynecologica Scandinavica·S SuhonenP Lähteenmäki
Feb 23, 1999·Human Reproduction Update·S K Smith
Jun 22, 1999·Acta Obstetricia Et Gynecologica Scandinavica·T RaudaskoskiT Laatikainen
Jul 31, 1999·Fertility and Sterility·E Suvanto-Luukkonen, A Kauppila
Mar 26, 2002·Climacteric : the Journal of the International Menopause Society·M ReesR Bicknell
Mar 27, 2002·Climacteric : the Journal of the International Menopause Society·J H PickarD F Archer
Mar 27, 2002·Climacteric : the Journal of the International Menopause Society·S L NandG Z Heller

❮ Previous
Next ❯

Citations

Mar 16, 2007·The New England Journal of Medicine·Bruce A Bouts
Jan 1, 2008·Patient Preference and Adherence·Chandra Kailasam, David Cahill
Aug 27, 2009·Therapeutics and Clinical Risk Management·Megan N Beatty, Paul D Blumenthal
Mar 1, 2002·Human Reproduction·S HagueMargaret C P Rees
Sep 1, 2005·Women's Health·Regine Sitruk-Ware, Pirjo Inki
Jul 16, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Dirk WildemeerschNathalie de Wever
Jun 25, 2008·Expert Review of Medical Devices·Luis BahamondesIlza Monteiro
Mar 2, 2006·Expert Opinion on Drug Delivery·Ian S Fraser, Diana Mansour
Oct 27, 2007·Climacteric : the Journal of the International Menopause Society·D W Sturdee
Oct 25, 2011·Climacteric : the Journal of the International Menopause Society·Y-L Wan, C Holland
Mar 26, 2002·Climacteric : the Journal of the International Menopause Society·D W Sturdee
May 9, 2013·Climacteric : the Journal of the International Menopause Society·D W Sturdee
May 10, 2007·Climacteric : the Journal of the International Menopause Society·UNKNOWN Board of the International Menopause SocietyNick Panay
Aug 23, 2005·Climacteric : the Journal of the International Menopause Society·H Kuhl
Nov 28, 2008·Best Practice & Research. Clinical Obstetrics & Gynaecology·Jo Marsden, David Sturdee
Oct 31, 2008·Journal of Minimally Invasive Gynecology·Rhonda FlemmingAnne Jackson
Jan 10, 2006·Acta Clinica Belgica·J J Amy
Dec 6, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Rajesh VarmaJanesh K Gupta
Apr 28, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·D Wildemeersch
Mar 4, 2006·The Journal of the British Menopause Society·David Sturdee
Jul 11, 2006·The Journal of Family Planning and Reproductive Health Care·Franz M Ndumbe, Roy P Husemeyer
Apr 1, 2005·Climacteric : the Journal of the International Menopause Society·D W SturdeeUNKNOWN Multicenter MLS Investigators
Aug 2, 2005·Lancet·Martha HickeyDavid W Sturdee
Apr 16, 2021·Endocrine Reviews·Valerie A FloresJoAnn E Manson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Gender-specific Medicine : JGSM : the Official Journal of the Partnership for Women's Health at Columbia
N K GartrellS Thiemann
© 2022 Meta ULC. All rights reserved