Intrauterine death, fetal malformation, and delayed pregnancy in Ljungan virus-infected mice

Birth Defects Research. Part B, Developmental and Reproductive Toxicology
Annika SamsioeBo Niklasson

Abstract

A picornavirus (Ljunganvirus [LV]) has recently been associated with disease during pregnancy in its natural rodent reservoir and in humans. A study of laboratory mice infected under controlled conditions was therefore undertaken. CD-1 female mice were infected gestational day two and subjected to varying regimes of stress. LV infection in combination with stress resulted in uterine resorptions, malformations, and neonatal death. A short delay in time to first pregnancy and births was observed in pairs infected in utero. LV is found in different species of native animals in both Europe and the United States and human epidemiological evidence connects LV and human reproduction, while the observations here indicate that LV is responsible for reproductive problems in a laboratory mouse model. The current findings suggest that the hypothesis that LV also causes disease in pregnant women and their offspring deserves further study.

References

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Citations

May 2, 2009·Forensic Science, Medicine, and Pathology·Bo NiklassonWilliam Klitz
Dec 25, 2009·The New England Journal of Medicine·Andrea PorzionatoRaffaele De Caro
Dec 8, 2010·Expert Review of Anti-infective Therapy·Joanne G WildenbeestKatja C Wolthers
May 15, 2012·Journal of Virological Methods·René KalliesMatthias Niedrig
May 18, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·W Allan NixM Steven Oberste
Apr 12, 2008·Journal of Virological Methods·Conny TolfA Michael Lindberg
Jan 31, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Bo NiklassonWilliam Klitz
Jan 13, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Annika SamsioeBo Niklasson
Aug 21, 2008·Journal of Medical Virology·German TapiaKjersti S Rønningen
Oct 14, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Annika SamsioeWilliam Klitz
Mar 6, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Bo NiklassonWilliam Klitz
Oct 5, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Henry F Krous, Neil E Langlois
Mar 20, 2015·Birth Defects Research. Part C, Embryo Today : Reviews·Lili ZhengHong Xin
Feb 14, 2017·Journal of Wildlife Diseases·Cristina FevolaHeidi C Hauffe
Jun 27, 2020·JAD Reports·Bo NiklassonElisabet Englund

Related Concepts

Congenital Abnormality
Fetal Mummification
Mouse, Inbred ICRC
Picornaviridae Infections
Pregnancy Complications, Infectious

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