Intrauterine environment and later disease development: infertility treatment and the risk of diabetes in offspring

Medical Hypotheses
John Alcolado

Abstract

The phenotype of an individual, including their susceptibility to disease, is governed by several factors including parental genes and intrauterine environment. Thus, the risk of developing Type 2 diabetes is modulated by the inheritance of specific genetic variants that are slowly being characterised by the techniques of linkage analysis and population association studies using either a candidate gene or genome-wide scan approach. At the same time, evidence has accrued that alterations in the nutritional status of the developing foetus also increase the risk of diabetes in later life. Restricting protein intake in pregnant dams or interfering with placental function increases the risk of diabetes in offspring and light weight babies are more likely to develop Type 2 diabetes as adults than heavier ones. The oocyte plays a key role, since it contains not only the maternal haplotype but other information such as mitochondrial DNA and factors that modulate the expression of genes in the developing foetus. Although the ovaries contain a huge number of primordial follicles, generally each month only one oocyte matures to ovulation. Little is known about the processes that control this phenomenon. Certainly, primordial follicles and...Continue Reading

References

Oct 26, 1991·BMJ : British Medical Journal·C N HalesP D Winter
Nov 1, 1995·The Journal of Pediatrics·C P TalloR V Haning
Jun 1, 1995·Human Reproduction·R F Seamark, J S Robinson
Jan 1, 1993·Reproduction, Fertility, and Development·R J ScaramuzziA S McNeilly
Jan 28, 1999·Molecular and Cellular Endocrinology·R P Jansen, K de Boer
Nov 20, 2001·The Journal of Biological Chemistry·Yayoi Obata, Tomohiro Kono
Oct 9, 2002·International Journal of Experimental Diabetes Research·C J PetryC N Hales

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Citations

Aug 13, 2009·The Journal of Black Psychology·Serge MadhereCharmaine D M Royal

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