Intrauterine ethanol exposure results in hypothalamic oxidative stress and neuroendocrine alterations in adult rat offspring

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Korami DembeleB L Grégoire Nyomba

Abstract

Prenatal ethanol (EtOH) exposure is associated with low birth weight, followed by increased appetite, catch-up growth, insulin resistance, and impaired glucose tolerance in the rat offspring. Because EtOH can induce oxidative stress, which is a putative mechanism of insulin resistance, and because of the central role of the hypothalamus in the regulation of energy homeostasis and insulin action, we investigated whether prenatal EtOH exposure causes oxidative damage to the hypothalamus, which may alter its function. Female rats were given EtOH by gavage throughout pregnancy. At birth, their offspring were smaller than those of non-EtOH rats. Markers of oxidative stress and expression of neuropeptide Y and proopiomelanocortin (POMC) were determined in hypothalami of postnatal day 7 (PD7) and 3-mo-old (adult) rat offspring. In both PD7 and adult rats, prenatal EtOH exposure was associated with decreased levels of glutathione and increased expression of MnSOD. The concentrations of lipid peroxides and protein carbonyls were normal in PD7 EtOH-exposed offspring, but were increased in adult EtOH-exposed offspring. Both PD7 and adult EtOH-exposed offspring had normal neuropeptide Y and POMC mRNA levels, but the adult offspring had red...Continue Reading

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Citations

Feb 26, 2016·Neuroscience and Biobehavioral Reviews·Christine J FontaineBrian R Christie
Jul 31, 2012·The Journal of Nutritional Biochemistry·Anna R PattenBrian R Christie
Feb 15, 2011·Brain Research Reviews·Patricia S BrocardoBrian R Christie
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Jan 27, 2018·Antioxidants·Siti Syairah Mohd MutalipMohd Hamim Rajikin
Apr 5, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Qubo NiHui Wang
Mar 29, 2008·Alcoholism, Clinical and Experimental Research·Parri Wentzel, Ulf J Eriksson
Apr 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Xing-Hai Yao, B L Grégoire Nyomba
Nov 20, 2016·Alcoholism, Clinical and Experimental Research·Patricia S BrocardoBrian R Christie
Aug 8, 2020·Frontiers in Pediatrics·Laura AlmeidaMaría Dolores Gómez-Roig

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