Intrauterine exposure to maternal diabetes is associated with higher adiposity and insulin resistance and clustering of cardiovascular risk markers in Indian children.

Diabetes Care
Ghattu V KrishnaveniCaroline H D Fall

Abstract

To test the hypothesis that maternal gestational diabetes increases cardiovascular risk markers in Indian children. Anthropometry, blood pressure, and glucose/insulin concentrations were measured in 514 children at 5 and 9.5 years of age (35 offspring of diabetic mothers [ODMs], 39 offspring of diabetic fathers [ODFs]). Children of nondiabetic parents were control subjects. At age 9.5 years, female ODMs had larger skinfolds (P < 0.001), higher glucose (30 min) and insulin concentrations, and higher homeostasis model assessment (HOMA) of insulin resistance and systolic blood pressure (P < 0.05) than control subjects. Male ODMs had higher HOMA (P < 0.01). Associations were stronger than at age 5 years. Female ODFs had larger skinfolds and male ODFs had higher HOMA (P < 0.05) than control subjects; associations were weaker than for ODMs. Associations between outcomes in control subjects and parental BMI, glucose, and insulin concentrations were similar for mothers and fathers. The intrauterine environment experienced by ODMs increases diabetes and cardiovascular risk over genetic factors; the effects strengthen during childhood.

References

Dec 1, 1991·Diabetes·B L SilvermanB E Metzger
Dec 1, 1982·American Journal of Obstetrics and Gynecology·M W Carpenter, D R Coustan
Mar 31, 2005·The Journal of Clinical Endocrinology and Metabolism·Joy C BuntArline D Salbe
May 24, 2007·Diabetes Care·Teresa A HillierDavid J Pettitt
Nov 18, 2008·Diabetes·UNKNOWN HAPO Study Cooperative Research Group
Nov 22, 2008·American Journal of Hypertension·Charmaine S WrightEmily Oken

❮ Previous
Next ❯

Citations

Feb 18, 2011·Maternal and Child Health Journal·Kesha Baptiste-RobertsFrederick L Brancati
Jul 26, 2012·Indian Journal of Pediatrics·Caroline H D Fall
Jun 22, 2013·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·R RetnakaranJ Hamilton
Dec 28, 2010·Journal de gynécologie, obstétrique et biologie de la reproduction·A Burguet
Oct 7, 2011·Annals of Pediatric Cardiology·Duggirala Sivaram PrasadBhagabati Charan Das
May 4, 2011·World Journal of Diabetes·Zhong-Cheng LuoAnne-Monique Nuyt
Dec 29, 2013·Diabetes Research and Clinical Practice·Subrina JesminTaro Mizutani
Jan 15, 2014·The Proceedings of the Nutrition Society·Jane L Tarry-Adkins, Susan E Ozanne
Jul 1, 2014·BioMed Research International·D C DamascenoM V C Rudge
Jul 6, 2014·Indian Pediatrics·G V KrishnaveniC H D Fall
Jan 23, 2013·Epidemiology·Casey CrumpJan Sundquist
Aug 4, 2011·Advances in Gerontology = Uspekhi Gerontologii·S S Moĭsa, A D Nozdrachev
Nov 20, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·O MafteiV M Moore
Jun 21, 2011·Annals of Human Biology·Caroline H D Fall
Aug 19, 2015·Free Radical Biology & Medicine·Sarah J ChappleGiovanni E Mann
Apr 13, 2011·The Journal of Pediatrics·Kathleen A Page, Thomas A Buchanan
Dec 21, 2010·Progress in Biophysics and Molecular Biology·Lucilla Poston
Dec 18, 2010·Diabetes & Metabolism·A Burguet
Sep 14, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Lucilla Poston
Dec 21, 2010·Acta Paediatrica·Nicola R WinderDavid J P Barker
May 21, 2014·Paediatric and Perinatal Epidemiology·Mary Lou ThompsonMichelle A Williams
Apr 3, 2016·Journal of Physiology and Biochemistry·Mervat Y HanafiMaher A Kamel
May 1, 2012·Medical Hypotheses·S W WenR Retnakaran
Mar 19, 2015·Journal of Diabetes and Its Complications·Jennifer R LawElizabeth J Mayer-Davis
Jan 7, 2014·The Journal of Pediatrics·Kathleen A PageAnny H Xiang
Mar 13, 2014·International Journal of Epidemiology·Ghattu V KrishnaveniCaroline H D Fall
Sep 3, 2013·Journal of Diabetes Research·Abdel-Baset M ArefMargit Semmler
Jun 25, 2010·Diabetes Care·Zhong-Cheng LuoAnne-Monique Nuyt
Jul 28, 2016·Frontiers in Public Health·Jonathan C K WellsChittaranjan S Yajnik
Aug 14, 2010·The International Journal of Lower Extremity Wounds·C S Yajnik, A V Ganpule-Rao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.