Intrauterine Growth Restriction Affects Cerebellar Granule Cells in the Developing Guinea Pig Brain

Developmental Neuroscience
Mary TolcosSandra Rees

Abstract

Intrauterine growth restriction (IUGR) can lead to adverse neurodevelopmental sequelae in postnatal life. However, the effects of IUGR on the cerebellum are still to be fully elucidated. A major determinant of growth and development of the cerebellum is proliferation and subsequent migration of cerebellar granule cells. Our objective was to determine whether IUGR, induced by chronic placental insufficiency (CPI) in guinea pigs, results in abnormal cerebellar development due to deficits suggestive of impaired granule cell proliferation and/or migration. CPI was induced by unilateral ligation of the uterine artery at mid-gestation, producing growth-restricted (GR) foetuses at 52 and 60 days of gestation (dg), and neonates at 1 week postnatal age (term approx. 67 dg). Controls were from sham-operated animals. In GR foetuses compared with controls at 52 dg, the external granular layer (EGL) width and internal granular layer (IGL) area were similar. In GR foetuses compared with controls at 60 dg: (a) the EGL width was greater (p < 0.005); (b) the IGL area was smaller (p < 0.005); (c) the density of Ki67-negative (postmitotic) granule cells in the EGL was greater (p < 0.01); (d) the somal area of Purkinje cells was reduced (p < 0.005...Continue Reading

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Citations

Aug 21, 2019·Frontiers in Physiology·Anzari AtikMary Tolcos
Jun 14, 2019·Frontiers in Physiology·Tamara YawnoSuzanne L Miller
Sep 29, 2020·Stem Cells Translational Medicine·Ruth GussenhovenReint K Jellema
Oct 28, 2018·Pediatric Research·Ivo BendixUrsula Felderhoff-Müser
Nov 15, 2018·Developmental Neuroscience·Jill L ChangMaria L V Dizon

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