Intrauterine Growth Restriction and Patent Ductus Arteriosus in Very and Extremely Preterm Infants: A Systematic Review and Meta-Analysis

Frontiers in Endocrinology
Eduardo Villamor-MartínezEduardo Villamor

Abstract

It is generally accepted that intrauterine growth restriction (IUGR) increases morbidity and mortality among very preterm neonates. However, evidence is hampered by the widespread practice of using the terms small for gestational age (SGA) and IUGR as synonyms. We conducted a systematic review of studies reporting on the association between IUGR/SGA and patent ductus arteriosus (PDA). PubMed/MEDLINE and EMBASE databases were searched. Of 993 studies reviewed, 47 (50,790 infants) were included. Studies were combined using a random effects model and sources of heterogeneity were determined by subgroup and meta-regression analyses. Meta-analysis of all included studies showed a significantly reduced risk of PDA in the SGA/IUGR group with an odds ratio (OR) of 0.82, and a 95% confidence interval (CI) of 0.70 to 0.96 (p = 0.015). Of the 47 studies, only 7 used a definition for growth restriction that went beyond birth weight (BW) for gestational age (GA). When pooled, meta-analysis could not demonstrate a significant effect size (OR 1.31, 95% CI 0.75 to 2.27, p = 0.343). Moreover, the significantly reduced risk of PDA was found in the 25 studies defining SGA as BW <10th percentile (OR 0.81, 95% CI 0.66 to 0.98, p = 0.032), but not i...Continue Reading

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Citations

Oct 6, 2020·Frontiers in Pediatrics·Johan C A de KlerkSinno H P Simons
May 11, 2021·Taiwanese Journal of Obstetrics & Gynecology·Chung-Yuan YangYao-Lung Chang
Oct 31, 2021·Pediatric Research·Philip T LevyUNKNOWN ESPR Special Interest Group “Near InfraRed Spectroscopy” (NIRS)

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Methods Mentioned

BETA
SGA

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SCR_012779

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