Intrauterine growth restriction in a rodent model and developmental programming of the metabolic syndrome: a critical appraisal of the experimental evidence

Placenta
Uta NeitzkeAndreas Plagemann

Abstract

Research on intrauterine growth restriction (IUGR) and subsequent development of obesity, type 2 diabetes and the metabolic syndrome is rapidly expanding, and potential implications for primary prevention are considerable. We have critically appraised one of the experimental animal models frequently used as mimic of human fetal growth restriction, which involves bilateral ligation of the uterine artery in rats (Lig). Our experimental study showed that Lig performed on day 17 of pregnancy neither leads to IUGR nor to neonatal catch-up growth, an important pathogenetic co-factor in humans. Meta-analysis of the literature revealed domination by studies in which Lig pups with IUGR were actively selected. Accordingly, publication bias is evident (p=0.007). Altered placental perfusion--the main cause of IUGR in humans in Western countries--neither led to IUGR nor to neonatal catch-up growth in Lig offspring, i.e., to none of the etiological factors of the human 'small baby syndrome'. Appropriate and reproducible rodent models of IUGR through decreased placental flow remain to be established to uncover the pathophysiological basis of the 'small baby syndrome'. This may lead to new strategies of primary prevention of diabetes, obesity,...Continue Reading

References

Jan 15, 1992·JAMA : the Journal of the American Medical Association·K DickersinC L Meinert
Sep 1, 1988·Pediatric Research·E S Ogata, S L Finley
Aug 1, 1988·Experimental and Clinical Endocrinology·G DörnerE Steindel
Jun 1, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A PlagemannG Dörner
Sep 7, 2000·The Journal of Endocrinology·E C HoudijkH A Delemarre-Vd Waal
Sep 13, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·T HarderA Plagemann
Feb 5, 2002·Pediatrics·Nicolas StettlerVirginia A Stallings
Sep 11, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Robert Gagnon
Jul 1, 1964·The Journal of Pathology and Bacteriology·J S WIGGLESWORTH
Nov 11, 2003·American Journal of Physiology. Endocrinology and Metabolism·Iyalla E PetersideRebecca A Simmons
Jan 30, 2004·Nature·Susan E Ozanne, C Nicholas Hales
Feb 28, 2004·BMJ : British Medical Journal·Pandora PoundUNKNOWN Reviewing Animal Trials Systematically (RATS) Group
Mar 27, 2004·European Journal of Pharmacology·Marijke SandersJo De Mey
Jun 4, 2004·The New England Journal of Medicine·Timothy BarrettEamonn Maher
Dec 9, 2004·JAMA : the Journal of the American Medical Association·Rachel HuxleyRory Collins
Jun 5, 2007·Lancet·Thomas HarderAndreas Plagemann

❮ Previous
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Citations

Jan 24, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Amanda N Sferruzzi-PerriAbigail L Fowden
Dec 7, 2011·Reproductive Biology and Endocrinology : RB&E·Elaine M P AmorimWilma D G Kempinas
Apr 3, 2010·PLoS Medicine·H Bart van der WorpMalcolm R Macleod
Mar 13, 2014·Current Opinion in Clinical Nutrition and Metabolic Care·Rehana A SalamZulfiqar A Bhutta
Sep 14, 2011·Annual Review of Physiology·Paolo Rinaudo, Erica Wang
Oct 31, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Eftychia AravidouGeorgios P Chrousos
Jan 21, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·B DeloisonL J Salomon
Mar 23, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Uta NeitzkeAndreas Plagemann
Oct 23, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·O VargaA K Hansen
Nov 10, 2013·Birth Defects Research. Part C, Embryo Today : Reviews·Sky Feuer, Paolo Rinaudo
Aug 29, 2012·Theriogenology·O MorelP Chavatte-Palmer
Jun 18, 2016·International Journal of Environmental Research and Public Health·Pascale Chavatte-PalmerDelphine Rousseau-Ralliard
Jan 29, 2018·Journal of Developmental Origins of Health and Disease·A BarberoF Berlinguer
Nov 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yasaman ShahkhaliliKatherine Macé
Nov 17, 2017·Journal of the Royal Society, Interface·J W HansonJ Lobo
Nov 6, 2010·Endocrine Reviews·Floor Remmers, Henriette A Delemarre-van de Waal
Sep 13, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Violeta StojanovskaTorsten Plösch
Mar 20, 2009·The American Journal of Clinical Nutrition·Michael E SymondsHelen Budge
Jul 12, 2019·Frontiers in Endocrinology·Linda van WykUNKNOWN DIGITAT study group
Mar 5, 2016·International Journal of Molecular Medicine·Yuehua ZhouYu Zeng
May 4, 2021·Frontiers in Neuroscience·Anastasios PotirisMakarios Eleftheriades

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