Intrauterine growth restriction predicts lower lung function at school age in children born very preterm

Archives of Disease in Childhood. Fetal and Neonatal Edition
Eveliina RonkainenMikko Hallman

Abstract

Children born preterm have lower lung function compared with term-born children. Intrauterine growth restriction (IUGR) may predispose individuals to chronic obstructive pulmonary disease. The purpose of this observational study was to investigate the role of IUGR as predictor of lung function at school age in children born very preterm. We further studied the difference in lung function between term-born and preterm-born children with distinct morbidities. Preterm-born children and age-matched and sex-matched term-born comparison groups (88 of each) were studied at the mean age of 11 years. Spirometry and diffusing capacity of the lung for carbon monoxide (DLCO) were recorded. All preterm-born subjects with IUGR (n=23), defined as birth weight less than -2 SD, were compared with preterm-born subjects without IUGR (n=65). In the preterm-born children exposed to IUGR, the forced expiratory volume in 1 s (FEV1) was 5.7 (95% CI -10.2 to -1.3) and DLCO 9.2 percentage points lower (95% CI -15.7 to -2.7) than in the preterm-born children with appropriate in utero growth (expressed as percentage of predicted values). The effect of IUGR in decreasing FEV1 and DLCO remained significant after adjustment for bronchopulmonary dysplasia (BP...Continue Reading

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Jul 4, 2017·Pediatric Pulmonology·Esther van MastrigtMariëlle W Pijnenburg
Dec 23, 2017·American Journal of Respiratory and Critical Care Medicine·Bradley WallaceSteven H Abman
Jun 3, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Chansutha ThangaratnarajahMiguel A Alejandre Alcázar
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Feb 27, 2020·American Journal of Respiratory and Critical Care Medicine·Gregory SeedorfSteven H Abman
Mar 2, 2017·American Journal of Respiratory and Critical Care Medicine·Lindsey A MorrowSteven H Abman
Feb 23, 2019·Frontiers in Endocrinology·Atul MalhotraSuzanne L Miller
Jun 20, 2020·American Journal of Respiratory and Critical Care Medicine·Kellen HirschSteven H Abman
Feb 26, 2021·Scientific Reports·Natalia El-MerhieSusanne Krauss-Etschmann
Mar 6, 2021·Pediatric Pulmonology·Christopher HarrisAnne Greenough
Nov 14, 2020·Scientific Reports·Maria ArroyasMaria Luz Garcia-Garcia
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Jul 3, 2021·Frontiers in Medicine·Celien Kuiper-MakrisMiguel A Alejandre Alcazar
Dec 12, 2021·Molecular and Cellular Pediatrics·Mitali Sahni, Vineet Bhandari

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