Intrauterine growth restriction results in persistent vascular mismatch in adulthood

The Journal of Physiology
Anderson H KuoPeter W Nathanielsz

Abstract

Intrauterine growth restriction (IUGR) increases offspring risk of chronic diseases later in life, including cardiovascular dysfunction. Our prior studies suggest biventricular cardiac dysfunction and vascular impairment in baboons who were IUGR at birth because of moderate maternal nutrient reduction. The current study reveals changes in artery sizes, distensibility, and blood flow pattern in young adult IUGR baboons, which may contribute to cardiac stress. The pattern of abnormality observed suggests that vascular redistribution seen with IUGR in fetal life may continue into adulthood. Maternal nutrient reduction induces intrauterine growth restriction (IUGR), increasing risks of chronic diseases later in life, including cardiovascular dysfunction. Using ultrasound, we determined regional blood flow, blood vessel sizes, and distensibility in IUGR baboons (8 males, 8 females, 8.8 years, similar to 35 human years) and controls (12 males, 12 females, 9.5 years). The measured blood vessels were larger in size in the males compared to females before but not after normalization to body surface area. Smaller IUGR normalized blood vessel sizes were observed in the femoral and external iliac arteries but not the brachial or common car...Continue Reading

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Citations

Jul 4, 2019·Journal of Paediatrics and Child Health·Domenico Umberto De RoseEloisa Tiberi
Oct 1, 2019·Journal of Developmental Origins of Health and Disease·Hillary F HuberPeter W Nathanielsz
Dec 1, 2018·The Journal of Physiology·L BennetA J Gunn
Feb 23, 2019·Frontiers in Endocrinology·Atul MalhotraSuzanne L Miller
Apr 27, 2019·Frontiers in Endocrinology·Immaculate M LangmiaRalf Dechend
Jul 4, 2020·Journal of Developmental Origins of Health and Disease·Anderson H KuoGeoffrey D Clarke
Apr 21, 2018·The Journal of Physiology·Geoffrey D Clarke, Peter W Nathanielsz
Jul 28, 2020·International Journal of Molecular Sciences·Huixia YangViktoria von Schönfeldt
Dec 23, 2020·Journal of Developmental Origins of Health and Disease·G D ClarkeP W Nathanielsz
Jul 25, 2021·International Journal of Molecular Sciences·Charmaine R RockBeth J Allison

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