Intrauterine growth retardation in foetuses of women with epilepsy

Seizure : the Journal of the British Epilepsy Association
Anette Huuse FarmenMorten Lossius

Abstract

Various factors may affect intrauterine foetal growth, amongst which conditions such as epilepsy and the use of anti-epileptic drugs (AED) may play a role. This study investigated intrauterine growth of foetuses in women with epilepsy, as compared with controls, and explored whether intrauterine growth was affected by prenatal exposure to AED. Data were obtained from prospectively registered data regarding pregnancy and prenatal and perinatal factors in women in Oppland County in Norway. The final analysis included information from 166 mothers with epilepsy and 287 children. The control group consisted of 40,553 pregnancies in women without epilepsy registered in the same database. There was a significantly higher risk of the ponderal index being below the 10th percentile and infants being small for gestational age (SGA) in the epilepsy group; exposure to AED increased the risk. The frequency of SGA and low ponderal index was highest in Lamotrigine exposed infants. In the AED group, head circumference was significantly smaller among Carbamazepine exposed. Impaired intrauterine growth of foetuses in women with epilepsy was identified. The frequency of SGA and low ponderal index was highest in Lamotrigine exposed infants. The epi...Continue Reading

References

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Jun 6, 2009·Epilepsia·Gyri VeibyNils E Gilhus
Oct 16, 2009·Seizure : the Journal of the British Epilepsy Association·Malin AlmgrenCatharina Lavebratt
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Sep 20, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ruby Benjamin-Garner, Angela Stotts

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Citations

Mar 8, 2017·Toxicology·R G Ahmed, A W El-Gareib
Jun 29, 2017·Birth Defects Research·Orna Diav-CitrinAsher Ornoy
Mar 20, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Barbara MostacciUNKNOWN and the ESPEA Study Group
Nov 11, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H FarmenM I Lossius
Nov 7, 2019·Archives of Gynecology and Obstetrics·Lara SüdekumAnke Rissmann
Sep 24, 2020·Revista brasileira de enfermagem·Ryanne Carolynne Marques GomesSuzana de Oliveira Mangueira
Jun 25, 2017·Archives of Gynecology and Obstetrics·Daijuan ChenBing Peng
Oct 19, 2017·British Journal of Clinical Pharmacology·Merav Cohen-IsraelNehama Linder

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