PMID: 12763129May 24, 2003Paper

Intrauterine infection and the development of cerebral palsy

BJOG : an International Journal of Obstetrics and Gynaecology
Bo Hyun YoonTinnakorn Chaiworapongsa

Abstract

Cerebral palsy is a serious motor disorder that appears in early life. The expectation that improved obstetrical and neonatal care would decrease the rate of this condition has not been realised. Recent evidence indicates that white matter brain lesions, often termed periventricular leukomalacia (PVL), are the most important identifiable risk factors for the development of cerebral palsy. The hypothesis under examination is that inflammatory cytokines released during the course of intrauterine infection play a central role in the genesis of preterm parturition, fetal PVL, and cerebral palsy. We examined the relationship between umbilical cord plasma concentrations of cytokines at birth and the occurrence of PVL in preterm gestation and demonstrated that umbilical cord plasma concentrations of interleukin (IL)-6 was a significant independent predictor of PVL-associated lesions. We also demonstrated that preterm neonates born to mothers with elevated amniotic fluid concentrations of pro-inflammatory cytokines were at increased risk for the subsequent development of PVL and cerebral palsy. Histological chorioamnionitis and congenital neonatal infection-related morbidity were more common in neonates with PVL than those without PVL ...Continue Reading

References

Jul 1, 1977·Annals of Neurology·F H GillesC S Kerr
Apr 1, 1992·Annals of Neurology·W R TyorD E Griffin
Mar 1, 1991·The Journal of Clinical Investigation·K SelmajC F Brosnan
Feb 1, 1990·Archives of Disease in Childhood·R W Cooke
Jan 1, 1988·American Journal of Obstetrics and Gynecology·F J Stanley, L Watson
Jul 10, 1986·The New England Journal of Medicine·K B Nelson, J H Ellenberg
Jul 1, 1984·Acta paediatrica Scandinavica·B HagbergI Olow
Aug 1, 1993·The Journal of Pediatrics·S K CumminsE M Velie
Mar 21, 1998·American Journal of Epidemiology·T M O'SheaR G Dillard
May 8, 1998·Obstetrics and Gynecology·J M AlexanderK J Leveno
Oct 16, 1999·The New England Journal of Medicine·O BaudT Lacaze-Masmonteil

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Citations

Mar 30, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Chong Jai KimJung-Sun Kim
Apr 8, 2006·Current Opinion in Pediatrics·Anthony D Edwards, Susern Tan
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Claudio De FeliceRobert J Kopotic
Jun 15, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Renato S Procianoy, Rita C Silveira
Apr 25, 2012·Neurology Research International·Ryan M McAdams, Sandra E Juul
Jun 22, 2012·Mediators of Inflammation·Lynne SykesPhillip R Bennett
Feb 20, 2004·Pediatric Research·Alan Leviton, Olaf Dammann
Jul 26, 2006·Pediatric Research·Jovanna DahlgrenAgneta Holmäng
Jul 28, 2012·International Journal of Critical Illness and Injury Science·Vevek ParikhSagar Galwankar
Sep 29, 2005·Pediatric Research·Ricardo A CaicedoJosef Neu
Oct 4, 2005·Obstetrics and Gynecology·Riikka AaltonenAnna Alanen
Mar 2, 2005·Obstetrics and Gynecology·Arsenio SpinilloElisa Fazzi
Mar 2, 2006·Obstetrics and Gynecology·Jeffrey M Perlman
Jun 28, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·J Neu
Oct 16, 2008·Developmental Neuroscience·M Daniela Bianco-BatllesVadim S Ten
Apr 28, 2009·Current Opinion in Infectious Diseases·Catalin S BuhimschiIrina A Buhimschi
Oct 1, 2011·Journal of Perinatal Medicine·Roberto RomeroMoshe Mazor
Apr 18, 2012·American Journal of Epidemiology·Ondine S von EhrensteinJun Zhang
Apr 29, 2006·Current Opinion in Infectious Diseases·Ira Adams-Chapman, Barbara J Stoll
Mar 9, 2010·Diagnostic Microbiology and Infectious Disease·David C KasperAngelika Berger
Aug 19, 2015·American Journal of Obstetrics and Gynecology·Omer MorOffer Erez
Nov 26, 2008·Clinics in Perinatology·Alistair Jan Gunn, Laura Bennet
Aug 9, 2005·Seminars in Pediatric Surgery·Josef NeuElizabeth Beierle
Oct 3, 2015·American Journal of Obstetrics and Gynecology·Chong Jai KimYeon Mee Kim
Oct 27, 2005·Annals of Neurology·Alan LevitonScott K Durum
May 18, 2006·The Journal of Comparative Neurology·Saraid S BilliardsHannah C Kinney
Feb 16, 2010·Journal of Neuroscience Research·Irina BurdMichal A Elovitz
Jan 3, 2013·American Journal of Reproductive Immunology : AJRI·Sun K KimTinnakorn Chaiworapongsa
Oct 15, 2013·Paediatric and Perinatal Epidemiology·Jessica E MillerJørn Olsen
Dec 31, 2009·American Journal of Reproductive Immunology : AJRI·Carl A NathMorgan R Peltier
Aug 16, 2013·The Journal of Obstetrics and Gynaecology Research·Kentaro KurasawaFumiki Hirahara
Jul 17, 2013·The Journal of Obstetrics and Gynaecology Research·Justine OuelletJean-Charles Pasquier
Feb 5, 2010·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A L Letti MüllerJ A De A Magalhães
Feb 5, 2005·Seminars in Fetal & Neonatal Medicine·H Logghe, J J Walker

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