Intrauterine infection of mice with St. Louis encephalitis virus: immunological, physiological, neurological, and behavioral effects on progeny.

Infection and Immunity
A A Andersen, R P Hanson

Abstract

Intravenous injection of pregnant mice with St. Louis encephalitis (SLE) virus at 8 days of gestation resulted in infection of the fetus. Progeny developed no antibody or tolerance to SLE virus since the viral antigen was cleared by maternal antibody before antibody-forming competence developed in the young. Temporary growth retardation was observed in a number of young at 3 weeks of age. After the initial setback the growth rate increased, indicating that early runting was due to an inability to adjust adequately to extrauterine life, which was subsequently overcome. In most other young there were no significant effects on growth, reproduction, or life expectancy. A few young died at or shortly after birth; in these, neurological changes ranging from gross defects such as encephaloceles and hydrocephalus to histological evidence of necrosis and congestion were observed. Neurologically related behavioral changes were detected by using the open field test and the rotating-rod test, which indicated neurological damage and memory impairment in the surviving intrauterinely infected animals.

References

May 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·J Hotcin, E Sikora
Jun 1, 1967·Journal of Comparative and Physiological Psychology·A E Whimbey, V H Denenberg
Jul 1, 1953·The Journal of Pediatrics·H R SHINEFIELD, T E TOWNSEND
Nov 1, 1950·Proceedings of the Society for Experimental Biology and Medicine·K F BURNS
Sep 1, 1970·Infection and Immunity·A A Andersen, R P Hanson

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Citations

Jul 1, 2016·Brain : a Journal of Neurology·Abelardo Q C AraujoAlexandra P Q C Araujo
May 8, 2019·Scientific Reports·Adriano de Bernardi Schneider, Michael T Wolfinger
Oct 29, 2017·Current Opinion in Virology·Derek J Platt, Jonathan J Miner
Jan 26, 2007·The Journal of General Virology·Laura CórdobaJuan-Carlos Saiz
Feb 2, 2018·Science Translational Medicine·Derek J PlattJonathan J Miner
May 1, 1981·Infection and Immunity·J García-TamayoA J Martínez

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