PMID: 9654178Jul 8, 1998Paper

Intrauterine irrigation with prostaglandin F2-alpha for management of severe postpartum hemorrhage

Acta Obstetricia Et Gynecologica Scandinavica
M J KupfermincJ B Lessing

Abstract

Severe postpartum hemorrhage is a significant contributor to maternal morbidity and mortality. The use of prostaglandin F2-alpha to control severe postpartum hemorrhage may avert surgery for the control of bleeding. After ruling out the possibility of genital tract injuries, 18 patients with severe postpartum hemorrhage caused by uterine atony were enrolled in the study. None of the patients responded to treatment with oxytocin, methylergonovine, or uterine massage. A Foley catheter was introduced into the uterine cavity and the balloon was inflated with 5 ml sterile saline solution. The catheter was connected to an infusion line of 500 ml saline solution containing 20 mg prostaglandin F2-alpha. The solution was infused at a rate of 3-4 ml/minute for the first 10 min, and then reduced to 1 ml/minute for a period of 12 24 hours. In 17 patients (94.4%) bleeding ceased within several minutes of initiation of intrauterine prostaglandin F2-alpha infusion, the uterus was firmly contracted and uterine bleeding did not recur. In one patient with placenta increta bleeding continued and hysterectomy was performed. None of the patients had any side effects. Intrauterine irrigation with low concentrations of prostaglandin F2-alpha is a sim...Continue Reading

Citations

Jul 21, 2011·Journal of Anaesthesiology, Clinical Pharmacology·Neha BaduniAruna Jain
Oct 27, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J BlumB Winikoff

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