Intrauterine pressure, ischemia markers, and experienced pain during administration of a vasopressin V1a receptor antagonist in spontaneous and vasopressin-induced dysmenorrhea

Acta Obstetricia Et Gynecologica Scandinavica
Ragner LiedmanMats Akerlund

Abstract

A model to study the effect of vasopressin V1a antagonist in dysmenorrhea. A double-blind, randomized, placebo-controlled, cross-over trial was performed. Eight patients with primary dysmenorrhea and eight tuballigated, healthy subjects participated on days 1-2 of two consecutive menstruations. At each menstruation a bolus injection of 10 pmol/kg of vasopressin was administered before and during infusion of either 300 microg/min of atosiban or placebo. Intrauterine pressure was measured as area under the curve throughout the experiments. Ischemia markers in plasma and pain recorded by a visual analog scale were measured before and after each vasopressin injection as well as before and after the start of either atosiban or placebo infusion. Vasopressin injections elevated area under the curve in both healthy volunteers and dysmenorrhea subjects. The vasopressin-induced rise in area under the curve was lower during atosiban administration than during infusion of placebo in both groups. None of the ischemia markers differed between or within groups at vasopressin injections or atosiban/placebo infusions. In subjects with dysmenorrhea the increase in pain following the administration of vasopressin was significantly lower during at...Continue Reading

Citations

Oct 18, 2012·Physiological Reviews·Taka-aki KoshimizuAkito Tanoue
Apr 7, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ragner LiedmanMats Akerlund
Jun 26, 2008·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Pedro Royo, Juan Luis Alcázar
Feb 20, 2020·International Journal of Environmental Research and Public Health·Zofia BarcikowskaKatarzyna Zorena
Jul 1, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·S L CohenJ I Einarsson

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