Intrauterine repair of cleft lip-like defects in lambs with a novel microclip

The Journal of Craniofacial Surgery
M L EvansR A Hardesty

Abstract

Potential for scarless wound healing in fetal surgeries has aroused interest in fetal repair of malformations such as cleft lip. However, current protocols for fetal surgery have entailed fetal externalization, imparting significant risks for mother and fetus. We have developed a unique silver microclip that rapidly approximates tissue, is nonpenetrating, and is well suited for endoscopic use. Using standardized intrauterine surgical techniques, we compared suture versus microclip in the repair of surgically created cleft-like defects in fetal lambs at 124 days' gestation (term, 145 days). Nine fetal lambs were analyzed with bilateral cleft lips; the right cleft was repaired by microclip, seven of the left clefts were repaired by suture, and the remaining two left clefts were not approximated (controls). Results demonstrated excellent wound healing and smooth lip continuity with minimal scar formation after repair by either microclip or suture. The most striking result, however, was in the comparison on intraoperative repair time; the total time for cleft lip repair by microclip averaged 2.5 minutes in contrast to 9.8 minutes for suture. These data suggest a distinct advantage of the microclip in reduction of operative time. Fu...Continue Reading

Citations

Jul 9, 1998·Plastic and Reconstructive Surgery·K C ObergR A Hardesty
Nov 21, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Matthias Heinrich Otto WenghoeferStefaan Bergé
Jul 5, 2005·British Journal of Plastic Surgery·N A PapadopulosE Biemer
Jul 21, 2004·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Shoichi SuzukiKimie Ohyama
Jul 18, 2003·The Journal of Craniofacial Surgery·H Peter Lorenz, Michael T Longaker
Dec 14, 2017·Annual Review of Animal Biosciences·Sandra K KabagambeDiana L Farmer
May 10, 2002·Head & Neck·Wolfgang Wagner, Michael R Harrison
Apr 9, 1998·Perfusion·J J Sistino
Sep 28, 1999·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·B J Mehrara, M T Longaker
Oct 7, 1998·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·E J StelnickiM T Longaker

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