Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner

Scientific Reports
Stefan DehmelS Krauss-Etschmann

Abstract

Prenatal exposure to tobacco smoke is a significant risk-factor for airway disease development. Furthermore, the high prevalence of pregnant smoking women requires the establishment of strategies for offspring lung protection. Therefore, we here aimed to understand the molecular mechanism of how prenatal smoke exposure affects fetal lung development. We used a mouse model recapitulating clinical findings of prenatally exposed children, where pregnant mice were exposed to smoke until c-section or spontaneous delivery, and offspring weight development and lung function was monitored. Additionally, we investigated pulmonary transcriptome changes in fetal lungs (GD18.5) by mRNA/miRNA arrays, network analyses and qPCR. The results demonstrated that prenatally exposed mice showed intrauterine and postnatal growth retardation, and impaired lung function. 1340 genes and 133 miRNAs were found to be significantly dysregulated by in utero smoke exposure, and we identified Insulin-like growth factor 1 (Igf1) as a top hierarchical node in a network analysis. Moreover, Igf1 mRNA was increased in female murine offspring and in prenatally exposed children. These findings suggest that prenatal smoking is associated with a dysregulation of sever...Continue Reading

References

Jan 1, 1992·American Journal of Respiratory Cell and Molecular Biology·L RaabergD Warburton
Jun 1, 1990·Metabolism: Clinical and Experimental·K C CopelandT L McAuliffe
Jan 1, 1987·Experimental Lung Research·J S Torday, H C Nielsen
Jan 1, 1994·Annual Review of Physiology·P Minoo, R J King
Apr 1, 1997·Paediatric and Perinatal Epidemiology·B L HortaF C Barros
Jan 15, 1998·Lancet·P G HepperJ C Dornan
Apr 13, 1999·American Journal of Preventive Medicine·A CastlesM L Boulton
Jun 29, 1999·Endocrinology·J WangC Bondy
Nov 24, 1999·Thorax·M R Becklake, F Kauffmann
Dec 14, 2002·American Journal of Respiratory and Critical Care Medicine·Frank D GillilandJohn M Peters
Sep 9, 2004·British Journal of Cancer·A G RenehanS M Shalet
Aug 24, 2005·Paediatric and Perinatal Epidemiology·Kate E PickettRosalind Wright
Feb 18, 2006·American Journal of Respiratory and Critical Care Medicine·Hanns MoshammerTony Fletcher
Jul 18, 2006·Nucleic Acids Research·Johannes RainerZlatko Trajanoski
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maike K Pincus-KnackstedtPetra C Arck
Apr 18, 2007·Current Allergy and Asthma Reports·Barbro N MelgertDirkje S Postma
May 9, 2008·Nature·Ross J MetzgerMark A Krasnow
Oct 22, 2008·Annals of Human Biology·Ali DelpishehBernard J Brabin
Jan 9, 2009·The European Respiratory Journal·M J BlacquièreM N Hylkema
Aug 22, 2009·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Vicki L CliftonRoger Smith
Jul 14, 2010·European Journal of Medical Research·D BeyerA Gillissen
May 14, 2010·Metabolism: Clinical and Experimental·Melissa SuterKjersti Aagaard-Tillery
May 11, 2011·International Journal of Environmental Research and Public Health·Gert S Maritz, Richard Harding
Sep 23, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Melissa SuterKjersti M Aagaard-Tillery
Apr 21, 2012·Developmental Cell·Madhu M OusephGustavo Leone
May 23, 2012·American Journal of Obstetrics and Gynecology·Jelmer R PrinsBarbro N Melgert
Jun 2, 2012·American Journal of Respiratory Cell and Molecular Biology·Atsuyasu SatoMachiko Ikegami
Aug 24, 2012·PloS One·Yan XuJeffrey A Whitsett
Sep 20, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ruby Benjamin-Garner, Angela Stotts
Jan 11, 2013·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Jeovany Martínez-MesaPedro C Hallal

❮ Previous
Next ❯

Citations

Jun 24, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Khosbayar LkhagvadorjMachteld N Hylkema
Apr 4, 2019·Frontiers in Pediatrics·Andrew Bush
Feb 21, 2019·Clinical Epigenetics·Razia ZakaryaBrian G Oliver
Sep 24, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Barbara HammerSusanne Krauss-Etschmann
Oct 10, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ettore LignelliRory E Morty
Jul 14, 2020·Current Pathobiology Reports·Roberto I MotaEdward M Bahnson
Nov 1, 2020·Allergy·Julie WeidnerMadeleine Rådinger
Oct 14, 2020·Reproductive Toxicology·J B ArmengaudU Simeoni
May 15, 2021·Environment International·Xiaotong JiNan Sang

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
PCR
cesarean section

Software Mentioned

Ingenuity®
CARMAweb
IPA®
Affymetrix
GraphPAD Prism
SAS
GraphPad
IPA® Pathway Analysis ( QIAGEN

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.