PMID: 11900200Mar 20, 2002Paper

Intravascular brachytherapy of the coronary arteries

Physics in Medicine and Biology
R A Fox

Abstract

This is a review of the relatively recently developed field of intravascular brachytherapy of coronary arteries. It presents a brief overview of the discipline of coronary angioplasty describing the problem of restenosis and discusses the potential for ionizing radiation to overcome this problem. It examines the various methods that have been used to irradiate the coronary arteries comparing their advantages and disadvantages. Special consideration is given to seeds and wires in the artery, radioactive liquids in the angioplasty balloon and radioactive stents. Passing reference is made to a number of other methods that have also been proposed, but which are not commonly used to irradiate the coronary arteries at present. The dosimetry of each of the major techniques is discussed and the data from different laboratories compared. Specific consideration is given to the need for centring of the radioactive source and the factors affecting the selection of a dose prescription. A brief review of recent clinical trials is followed by an examination of possible future directions in this field including the use of intravascular ultrasound to improve dosimetry, the use of gas-filled balloons to enhance the penetration of beta-emitting s...Continue Reading

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Citations

May 19, 2007·Australasian Physical & Engineering Sciences in Medicine·L D Oliver
Jan 29, 2008·Radiation Protection Dosimetry·A Sh Aydarous
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Feb 18, 2005·Physics in Medicine and Biology·Sung-Woo Lee, Warren Daniel Reece

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