Intravascular clearance of parasitized erythrocytes in rodent malaria

The Journal of Clinical Investigation
T C Quinn, D J Wyler

Abstract

Little is known about host defense mechanisms responsible for protective immunity in malaria. The intravascular location of the infection suggested that removal of parasitized erythrocytes by reticuloendothelial organs might be important. To study this possibility, we examined the clearance of (51)Crlabeled Plasmodium berghei-infected erythrocytes in rats. Infected erythrocytes were removed more rapidly from circulation than homologous uninfected erythrocytes. The rate of clearance of infected cells during the 1st hour after inoculation was approximately three times greater in rats rendered immune by prior infection than in control rats. This accelerated clearance resulted from greater splenic uptake in immune rats and appeared to correlate with spleen size. Since the clearance pattern of infected erythrocytes more closely resembled the clearance of Heinz body-containing uninfected erythrocytes than of antibody-coated (immunoglobulin G) uninfected erythrocytes, rheologic alterations of parasitized erythrocytes might be a more important determinant of clearance than an antibody-dependent process. During the phase of malaria infection in which increasing parasitemia is observed, organ uptake of infected erythrocytes did not incre...Continue Reading

References

Aug 1, 1970·The American Journal of Medicine·R I Weed
Dec 1, 1970·Archives of Internal Medicine·T M Saba
Jul 26, 1969·Nature·S CohenR B Crandall
Nov 1, 1966·The American Journal of Medicine·R A Rifkind
Aug 1, 1969·Experimental Parasitology·H L Lucia, R S Nussenzweig
Mar 29, 1957·Science·H F DEUTSCH, J I MORTON
Jan 1, 1960·The Journal of Experimental Medicine·D ROWLEY

❮ Previous
Next ❯

Citations

Aug 1, 1990·Immunology Letters·S Kumar, L H Miller
Aug 1, 1990·Immunology Letters·L Weiss
Jun 27, 2002·Journal of Gastroenterology and Hepatology·Michael S NobesRichard B Sewell
Apr 21, 1983·The New England Journal of Medicine·D J Wyler
Sep 10, 1987·The New England Journal of Medicine·S LooareesuwanD J Wyler
Dec 21, 2011·The Journal of Experimental Medicine·Jannik FonagerBlandine M D Franke-Fayard
Jan 1, 1982·Immunological Reviews·R J Howard
Apr 1, 1987·Scandinavian Journal of Immunology·A KharazmiB J Andersen
Jul 1, 1984·The American Journal of Anatomy·L Weiss, H Sakai
Nov 13, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·L H MillerT J Hadley
Oct 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura K ErdmanKevin C Kain
Jul 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·David S KhouryMiles P Davenport
Aug 22, 2018·Immunological Reviews·David S KhouryMiles P Davenport
Jan 20, 2021·Journal of Leukocyte Biology·Debopam Ghosh, Jason S Stumhofer
Nov 1, 1983·Infection and Immunity·C F Ockenhouse, H L Shear
Jan 6, 2021·Current Drug Metabolism·Ana C A X De-Oliveira, Francisco J R Paumgartten

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

The Anatomical Record
V R Mysorekar, A N Nandedkar
Transactions of the Royal Society of Tropical Medicine and Hygiene
H M Vincent, R J Wilson
© 2021 Meta ULC. All rights reserved