In seven of 30 consecutive patients with the adult respiratory distress syndrome, disseminated intravascular coagulation (DIC) developed. Increasing respiratory dysfunction characterized by decreased effective static compliance and increased hypoxemia coincided with the development of DIC. Patients in whom DIC developed were characterized by a high incidence of bleeding, gangrene of the extremities, renal dysfunction, mortality and autopsy evidence of fibrin microthrombi in the lungs, kidney and skin. In 12 of 23 patients who did not meet the criteria for DIC, the platelet count decreased by at least 50 per cent of the initial values at some time during their illness. Fibrin microthrombi were found in the lungs in the majority of the patients subjected to autopsy. These data support the concept that depostion of platelet on damaged pulmonary capillary endothelium may be more common in the adult respiratory distress syndrome than the DIC syndrome.
Contact phase of blood coagulation in cardiogenic pulmonary oedema (CPO) and adult respiratory distress syndrome (ARDS)
Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome
Effects of various doses of antithrombin III on endotoxin-induced endothelial cell injury and coagulation abnormalities in rats
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 5-1992. A 20-year-old man with diffuse pulmonary infiltrates and disseminated intravascular coagulation
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-1999. A 53-year-old man with acute renal failure, cortical blindness, and respiratory distress
Urokinase-type plasminogen activator (uPA) induces pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial nitric-oxide synthase.
Cytokines and plasminogen activator inhibitor-1 in posttrauma disseminated intravascular coagulation: relationship to multiple organ dysfunction syndrome
Gabexate mesilate, a synthetic protease inhibitor, attenuates endotoxin-induced pulmonary vascular injury by inhibiting tumor necrosis factor production by monocytes
Thrombocytopenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome
Acute systemic lupus erythematosus with fatal pneumonitis and disseminated intravascular coagulation
Incidence of pulmonary thromboembolism, infarction and haemorrhage in disseminated intravascular coagulation: a necroscopic analysis
Procoagulant activity in bronchoalveolar lavage in the adult respiratory distress syndrome. Contribution of tissue factor associated with factor VII
Neutrophil accumulation and structural changes in nonpulmonary organs after acute lung injury induced by phorbol myristate acetate
Urokinase plasminogen activator regulates pulmonary arterial contractility and vascular permeability in mice
Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management
Alveolar fluid neutrophil elastase activity in the adult respiratory distress syndrome is complexed to alpha-2-macroglobulin
Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial
Thrombocytopenia is associated with acute respiratory distress syndrome mortality: an international study
Blood Clotting Disorders
Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.