PMID: 1202908Jan 1, 1975Paper

Intravascular coagulation in pregnancy--treatment with heparin

Acta Obstetricia Et Gynecologica Scandinavica
I M NilssonS Ohrlander

Abstract

Two pregnant women with a history of miscarriages or premature labour are described. In the 25-27th week of pregnancy routine examinations showed high levels of FDP in serum. Subsequent extensive coaggulation studies revealed a positive ethanol gelation test, low levels of firbrinogen, plasminogen, alpha2-macroglobulin and P&P and high level of AHF related protein for the stage of pregnancy, i.e. finding indicating abnormal proteolysis with activation of the coagulation and fibrinolytic system. Continuous intravenous heparin treatment caused the coagulation system to return to normal throughout the rest of pregnancy. Both women gave birth to healthy babies without any complications. But the placenta showed numerous infarcts. The heparin treatment may have prevented later developing of placental dysfunction.

Citations

Oct 1, 1980·European Journal of Obstetrics, Gynecology, and Reproductive Biology·B BoneuG Pontonnier
Mar 1, 1981·British Journal of Obstetrics and Gynaecology·A FournieR Bierme
Sep 11, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·G DryllisM Politou

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