Intravascular delivery of particulate systems: does geometry really matter?

Pharmaceutical Research
Paolo DecuzziMauro Ferrari

Abstract

In cancer therapy and imaging, the systemic passive delivery of particulate systems has relied on the enhanced permeability and retention (EPR) effect: sufficiently small particles can cross the endothelial fenestrations and accumulate in the tumor parenchyma. The vast majority of man-made particulates exhibit a spherical shape as a result of surface energy minimization during their synthesis. The advent of phage display libraries, which are revealing the extraordinary molecular diversity of endothelial cells, and the development of processes for fabricating particles with shapes other than spherical are opening the path to new design solutions for systemically administered targeted particulates. In this paper, the role of particle geometry (i.e., size and shape) is discussed at the tissue and cellular scales. Emphasis is placed on how the synergistic effect of particle geometry and molecular targeting can enhance the specificity of delivery. The intravascular delivery process has been broken into three events: margination, firm adhesion and control of internalization. Predictions from mathematical models and observations from in-vitro experiments were used to show the relevance of particle geometry in systemic delivery. Ration...Continue Reading

References

Jan 1, 1967·Annual Review of Pharmacology·C Heidelberger
Mar 1, 1984·Microvascular Research·H L Goldsmith, S Spain
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S K HobbsR K Jain
Jul 17, 1998·Experimental Cell Research·M KovalT H Steinberg
Mar 22, 2001·Biophysical Journal·V R Shinde PatilD J Goetz
Nov 10, 2001·Annual Review of Biomedical Engineering·R K Jain
May 14, 2004·Pharmaceutical Research·Andreas IllingMichel H J Koch
May 27, 2004·Journal of the American Chemical Society·Fumio OsakiYasuhiro Aoyama
Feb 25, 2005·Current Pharmaceutical Biotechnology·Punit Kohli, Charles R Martin
Mar 2, 2005·Nature Reviews. Cancer·Mauro Ferrari
Mar 5, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S Moein MoghimiJ Clifford Murray
Mar 18, 2005·Annals of Biomedical Engineering·P DecuzziM Ferrari
Jun 2, 2005·Nature Reviews. Cancer·Dario Neri, Roy Bicknell
Jun 18, 2005·International Journal of Pharmaceutics·Camilla FogedAnne Sundblad
Jun 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Huajian GaoLambert B Freund
Jul 14, 2005·Journal of the American Chemical Society·Jason P RollandJoseph M DeSimone
Dec 16, 2005·Nature·Anand Bala SubramaniamHoward A Stone
Jan 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Glauco R SouzaRenata Pasqualini
Apr 12, 2006·Proceedings of the National Academy of Sciences of the United States of America·Omid C FarokhzadRobert Langer
Apr 13, 2006·Nano Letters·B Devika ChithraniWarren C W Chan
Apr 26, 2006·Journal of Cell Science·Marc HerantMicah Dembo
Sep 2, 2006·Analytical Chemistry·Glauco R SouzaJ Houston Miller
Oct 28, 2006·Science·Y HanA G Yodh
Nov 25, 2006·Advanced Drug Delivery Reviews·Anna SergeevaWadih Arap
Jul 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Julie A ChampionSamir Mitragotri
Aug 9, 2007·Expert Opinion on Drug Delivery·Jason SakamotoMauro Ferrari
Oct 16, 2007·Biomaterials·Paolo Decuzzi, Mauro Ferrari
Feb 1, 2008·Biophysical Journal·P Decuzzi, M Ferrari
Jul 26, 2008·Nature Nanotechnology·Mauro Ferrari

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Citations

Jul 30, 2008·Biomedical Microdevices·Takemi TanakaMauro Ferrari
Jun 4, 2013·Biomaterials·Abhijit A Date, Christopher J Destache
Nov 13, 2013·The Breast : Official Journal of the European Society of Mastology·Elvin Blanco, Mauro Ferrari
Jun 4, 2013·International Journal of Pharmaceutics·Roman MathaesAhmed Besheer
Jun 12, 2010·Biomacromolecules·Shihu Wang, Elena E Dormidontova
Nov 10, 2009·Biomacromolecules·Hadrian Djohari, Elena E Dormidontova
May 20, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Li Leo MaKeith P Johnston
Apr 13, 2012·Molecular Pharmaceutics·Yunqi ZhaoM Laird Forrest
Dec 5, 2009·Molecular Pharmaceutics·Tianyi M KrupkaAgata A Exner
Dec 27, 2011·Nano Letters·Kaustabh GhoshDonald E Ingber
Dec 20, 2008·Nature Materials·Samir Mitragotri, Joerg Lahann
Sep 15, 2010·Nature Reviews. Clinical Oncology·Rakesh K Jain, Triantafyllos Stylianopoulos
Jul 21, 2010·Nanoscale·Rita E SerdaMauro Ferrari
Jun 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jin-Wook Yoo, Samir Mitragotri
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Steven D Perrault, Warren C W Chan
Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Rachit AgarwalKrishnendu Roy
May 1, 2010·Cancer Research·Takemi TanakaMauro Ferrari
Aug 17, 2010·Journal of Nanobiotechnology·Hui Xie, Jeffrey W Smith
Jan 22, 2011·PloS One·Pubudu M PeirisEfstathios Karathanasis
Mar 8, 2013·PloS One·Hermann B FrieboesVittorio Cristini
Oct 1, 2011·Nanomedicine·Mark D Pagel
Aug 6, 2013·International Journal of Molecular Sciences·Arati G KolhatkarT Randall Lee
Dec 6, 2012·Beilstein Journal of Nanotechnology·Dave Maharaj, Bharat Bhushan
Jul 11, 2013·Nanomedicine·Yanping DingGuangjun Nie
Jun 27, 2013·Nanomedicine·Isaac M AdjeiVinod Labhasetwar
Jan 18, 2013·Therapeutic Delivery·Srinivas Ramishetti, Leaf Huang
Dec 4, 2012·Nanomedicine·Shaolie S HossainPaolo Decuzzi
May 17, 2014·Computational Mechanics·Kassandra FronczykPaolo Decuzzi
May 30, 2014·Journal of the Royal Society, Interface·Gang BaoBernhard Schrefler
Nov 21, 2013·Biotechnology Advances·Ping-Chang LinRajagopalan Sridhar
Feb 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Julia VoigtV Prasad Shastri
Jan 1, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Arong GaowaKoji Kawakami
Aug 15, 2013·Biomechanics and Modeling in Mechanobiology·Shaolie S HossainPaolo Decuzzi

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