PMID: 2117642Sep 1, 1990Paper

Intravascular filarial parasites elaborate cyclooxygenase-derived eicosanoids

The Journal of Experimental Medicine
L X LiuP F Weller

Abstract

The nematode parasites that cause human lymphatic filariasis survive for long periods in their vascular habitats despite continual exposure to host cells. Since prostanoids formed from arachidonic acid can modulate interactions among platelets, leukocytes, and endothelial cells, we examined whether intravascular nematode parasites can elaborate prostanoids. Microfilariae of Brugia malayi utilize exogenous and endogenous arachidonic acid to generate and release two predominant prostanoids, prostacyclin and prostaglandin E2. Filarial metabolism of host fatty acids to form these vasodilatory, antiaggregatory, and immunomodulatory eicosanoids provides a means by which these helminthic parasites may influence host immune and other cellular responses.

References

Aug 1, 1989·Experimental Parasitology·L X Liu, P F Weller
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Citations

Nov 1, 1991·Molecular and Biochemical Parasitology·N Kanesa-thasanJ W Kazura
Sep 1, 1995·Parasitology Today·A Belley, K Chadee
Mar 26, 1998·International Journal for Parasitology·A Daugschies, B Ruttkowski
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Apr 18, 1991·The New England Journal of Medicine·P F Weller
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Jun 6, 2012·PLoS Neglected Tropical Diseases·E James LaCoursePeter M Brophy
Apr 15, 2014·European Journal of Pharmacology·Christina Alves Peixoto, Bruna Santos Silva
Oct 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·L De Petrocellis, V Di Marzo
Nov 1, 1990·Experimental Parasitology·L X Liu, P F Weller
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Jan 5, 2017·The Journal of Veterinary Medical Science·Yasuhiro TakashimaKatsuya Kitoh
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Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zeina JaffarKevan Roberts
Dec 17, 2004·The Journal of Experimental Biology·Andrew F RowleyAnthony S Clare

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