PMID: 6104085Jun 14, 1980Paper

Intravascular haemolysis and renal impairment after blood transfusion in two patients on long-term 5-fluorouracil and mitomycin-C

Lancet
B G JonesV S Brookes

Abstract

In a multicentre trial of adjuvant chemotherapy in gastric adenocarcinoma, a number of patients developed chronic haemolysis and renal failure following long-term treatment with 5-fluorouracil and mitomycin-C. This was exacerbated by blood transfusion, leading to an acute intravascular haemolytic state accompanied by rapid decline in renal function. One patient investigated extensively was treated with antiplatelet drugs, steroids, and fresh frozen plasma without success. At necropsy this patient and another had renal changes typical of the haemolytic-uraemic syndrome and no evidence of tumour recurrence. Long-term treatment with this drug combination is potentially dangerous, and routine monitoring of renal function is recommended.

References

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Jan 1, 1985·Journal of Cancer Research and Clinical Oncology·J van der MeerJ G Aalders
Jan 30, 2004·The American Journal of Medicine·Nicola Zetola-Burneo, Cynthia Brown
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