Intravascular large B-cell lymphoma of the uterus: a case with favorable clinical outcome

International Journal of Surgical Pathology
Tomoko YamamotoMakio Kobayashi

Abstract

Intravascular lymphoma (IVL) of the uterus, a rare manifestation of malignant lymphoma, was diagnosed in a 71-year-old woman, who had fever, edema, and genital bleeding. Only 4 cases of uterine IVL have been reported in detail in the literature in English, to the author's knowledge. The patient was treated with total hysterectomy with bilateral salpingo-oophorectomy, accompanied by subsequent chemotherapy in combination with rituximab. Preoperative endometrial cytology and biopsy showed atypical lymphocytes intermingled with nonneoplastic epithelial cells. Intravascular proliferation of atypical lymphocytes was detected by histological examination of the resected materials, in which almost the entire uterine structure, including a large endometrial polyp, ovaries, and uterine tubes were involved. Immunohistochemically, tumor cells were positive for CD20 and CD79a and negative for CD5 and CD10. In situ hybridization for Epstein-Barr virus was negative. IVL generally has a poor prognosis. However, in the present case, the patient has been disease free for at least 51 months, and a favorable outcome can be expected.

References

Oct 24, 1998·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A MasunagaS Itoyama
Feb 5, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·R VangM Deavers
Jul 26, 2003·Internal Medicine·Ayumi FukushimaYoshiya Tanaka
Nov 15, 2003·International Journal of Surgical Pathology·Paul TranchidaMargarita Palutke
Oct 6, 2004·British Journal of Haematology·Andrés J M FerreriUNKNOWN International Extranodal Lymphoma Study Group (IELSG)
Feb 8, 2005·The Breast : Official Journal of the European Society of Mastology·M MonteiroM L Orvalho
Feb 24, 2005·American Journal of Hematology·Noriko YamadaChihiro Shimazaki
Mar 23, 2005·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Monalisa SurDean Daya
Apr 26, 2005·American Journal of Hematology·Achille AoubaOlivier Hermine
Aug 21, 2007·Human Pathology·Sherif A Rezk, Lawrence M Weiss
Sep 11, 2007·Internal Medicine·Ikuo ShimizuHikaru Kobayashi
Oct 9, 2008·The Journal of Obstetrics and Gynaecology Research·Chi-Feng SuKan-Hung Luo

❮ Previous
Next ❯

Citations

May 28, 2014·Seminars in Diagnostic Pathology·Elizabeth Euscher, Anais Malpica
Jun 24, 2016·Journal of Clinical and Experimental Hematopathology : JCEH·Tomoko UchiyamaChiho Ohbayashi
Aug 31, 2017·Annals of Hematology·Jérôme HadjadjDavid Boutboul

❮ Previous
Next ❯

Methods Mentioned

BETA
X ray
biopsy
hysterectomy

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Related Papers

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
G B WitkinR L Reddick
The American Journal of Dermatopathology
Mohammad Alhaji, Ruxana T Sadikot
International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Monalisa SurDean Daya
© 2022 Meta ULC. All rights reserved