PMID: 9447387Feb 3, 1998Paper

Intravascular lymphomatosis: a case presenting with encephalomyelitis and reactive haemophagocytic syndrome diagnosed by renal biopsy

Histopathology
F Y ChengC S Ng

Abstract

To report an unusual instance of intravascular lymphomatosis presented with encephalomyelitis and reactive haemophagocytic syndrome. There was no skin involvement. The diagnosis was made on a renal biopsy. The marrow smear was air dried and stained with Diff-Quik. The tissue sections were stained with haematoxylin and eosin. Masson trichrome, periodic acid-Schiff's reagent, Elastic van Gieson's stain, modified hexamine-silver technique and Martius scarlet blue. Immunohistochemistry for CD45, CD20, CD45RO, Factor VIII related antigen, CD31 and CD34 was performed on paraffin-processed tissue. The marrow smear showed active haemophagocytosis in the histiocytes. The renal biopsy showed intravascular lymphomatosis with tumour cells positive for CD45 and CD20. The possibility of intravascular lymphomatosis should be considered in patients with reactive haemophagocytic syndrome where the underlying cause cannot be found after thorough investigation.

Citations

Mar 12, 2003·International Journal of Hematology·Masafumi ItoMasahiko Fujino
Oct 29, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tom TörnrothKaarle Franssila
Apr 2, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Brigitte K NixonBrian P Rubin
Mar 2, 2006·Clinical Lymphoma & Myeloma·Sanya Sukpanichnant, Sanan Visuthisakchai
Sep 8, 2006·Journal of Veterinary Internal Medicine·S L RaidalS R Raidal
Apr 6, 2002·Clinics in Laboratory Medicine·Antonio M Hernandez
May 22, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Magdalena Martusewicz-BorosRenata Langfort
Apr 7, 2017·Internal Medicine·Arnaud DesclauxJean-Francois Viallard
Oct 6, 2004·British Journal of Haematology·Andrés J M FerreriUNKNOWN International Extranodal Lymphoma Study Group (IELSG)
Oct 3, 1999·Archives of Pathology & Laboratory Medicine·T J TuckerR N Miranda
May 27, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jinil YooPraveen Chander

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