PMID: 11902454Mar 21, 2002Paper

Intravascular lymphomatosis of the lung and liver following eyelid lymphoma in a Chinese man and review of primary pulmonary intravascular lymphomatosis

Pathology
Seng Geok Nicholas GohPuay Hoon Tan

Abstract

Intravascular lymphomatosis (IVL) is characterised by an almost exclusive intravascular proliferation of malignant lymphoid cells, with the diagnosis often made only when the illness is in its terminal phase or at autopsy. We detail a case of IVL affecting the lung and liver of a 49-year-old Chinese man presenting primarily with lung symptoms and incidental findings of abnormal serum transaminase levels, the ante-mortem diagnosis being established on transbronchial lung biopsy and percutaneous liver biopsy specimens, respectively. Histology disclosed CD20 + CD5 - CD10 [corrected] - malignant large mononuclear B cells within the lumina of the blood vessels of the affected organs as well as sinusoids of the liver. Significantly, the patient had a history of large B cell lymphoma affecting the eyelid 18 months prior to the angiotropic disease, suggesting a possible link between the more common types of non-Hodgkin's lymphoma and IVL. A brief review of all cases of primary pulmonary intravascular lymphomatosis is also presented.

References

Jan 1, 1992·Journal of the American Academy of Dermatology·F López-GilP Umbert
Jan 15, 1990·Cancer·S A Yousem, T V Colby
Apr 1, 1987·Pathology, Research and Practice·K RembergerM Haider
Dec 1, 1986·Histopathology·J M TheakerP Easterbrook
Nov 26, 1997·American Journal of Hematology·E P GaborK E Mercola

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