Intravascular metabolism of normal and mutant mouse immunoglobulin molecules

European Journal of Immunology
R R PollockM D Scharff

Abstract

The metabolism of IgG immunoglobulins in the body is tightly regulated in order to maintain their intravascular concentration. Different subclasses may have different intravascular half-lives, and in the mouse, passively administered IgG2b disappears from the circulation more rapidly than IgG2a. We have attempted to localize the sequences in the constant region which are responsible for this difference by examining the intravascular metabolism of mutant immunoglobulins that were generated in tissue culture and have undergone deletions of individual constant region domains or contain different combinations of gamma 2b and gamma 2a CH2 and CH3 domains. Our results suggest that the regulation of intravascular metabolism is complex but indicate that sequences in the CH3 domain are important in determining the different intravascular half-lives of IgG2b and IgG2a antibodies in the mouse.

References

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Citations

Jan 13, 1998·Immunology Today·V Ghetie, E S Ward
Jul 1, 1997·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·D L GoldmanL S Zuckier
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Feb 28, 2009·Biochemical and Biophysical Research Communications·JaeSeon WonMuHyeon Choe
Mar 15, 2015·Molecular Immunology·E Sally WardRaimund J Ober
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Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia Shu-Yi LiGary M Winslow
Nov 1, 1992·Infection and Immunity·J MukherjeeA Casadevall

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