Intravascular radiation detectors for the detection of vulnerable atheroma

Journal of the American College of Cardiology
H William StraussVartan Ghazarossian

Abstract

An intravascular catheter was developed to identify inflammation in coronary atheroma. Inflammation in atheroma is associated with large numbers of macrophages. These cells have increased metabolism, increased expression of chemotactic receptors, and a high frequency of apoptosis-associated phosphatidylserine expression. Each of these parameters can be identified in vivo using specific radiolabeled agents: metabolism can be identified with 18F fluorodeoxyglucose (FDG), receptor expression with 99mTc monocyte chemotactic peptide-1, and apoptosis with 99mTc annexin V. The locally increased concentration of these tracers is readily demonstrable in experimental lesions by ex vivo autoradiography; however, the small lesion size makes it difficult to identify atheroma in the coronaries with conventional imaging equipment. In contrast, with a radiation-sensitive catheter, optimized to sense charged particle rather than gamma or x-radiation, specific lesions could be identified and localized. Charged particle radiation is emitted as a byproduct of nearly all radioactive decay but is typically most abundant in radionuclides that decay by beta emission (either positrons or negatrons). Prototype catheters, using a plastic scintillator mat...Continue Reading

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Citations

Apr 18, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Yan ZhaoNagara Tamaki
Apr 10, 2009·JACC. Cardiovascular Imaging·Morton J Kern, Jagat Narula
Apr 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Albert J Sinusas
May 22, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Matthew O'DonnellErnest V Garcia
Dec 7, 2013·Theranostics·Moritz WildgruberAlma Zernecke
Apr 18, 2008·Current Cardiology Reports·Mark P S Dunphy, H William Strauss
Feb 22, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·John J YoungGregg W Stone
Aug 29, 2007·Circulation·Farouc A JafferRalph Weissleder
Apr 30, 2010·Physics in Medicine and Biology·Polad M ShikhalievTong Xu
Jul 10, 2019·Expert Review of Medical Devices·Matthias N Van OosteromFijs W B Van Leeuwen
Feb 1, 2020·Cardiovascular Engineering and Technology·F FranchiM Rodriguez-Porcel
Apr 11, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Raiyan T ZamanLei Xing
Mar 7, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mark R Vesely, Vasken Dilsizian

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