Intravascular substance P dilates cerebral parenchymal vessels through a specific tachykinin NK1 receptor in cats

European Journal of Pharmacology
M KobariY Fukuuchi

Abstract

The role of substance P in the cerebral parenchymal circulation was examined in 19 anesthetized cats. The local cerebral blood volume in the temporoparietal cortex was measured by our photoelectric method. Cerebral blood volume reflects the cumulative dimensions of the parenchymal microvessels. Intravenous injection of 0.01, 0.1, and 1 mg/kg FK888 (N2-[(4R)-4-hydroxy-1-(1-methyl-1H-indol-3-yl) carbonyl-L-prolyl]-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide) , a selective tachykinin NK1 receptor antagonist, had no significant effects (compared to the vehicle, ethanol) on cerebral blood volume and mean arterial blood pressure. Intracarotid injection of 1, 10, 100 pmol/kg, and 1 nmol/kg substance P increased cerebral blood volume (P < 0.01) in a dose-dependent manner (maximal increase of 6.5% at 5 min). Following injection of 1 nmol/kg substance P, cerebral blood volume was initially reduced, possibly due to the marked fall in mean arterial blood pressure (P < 0.01). The cerebral blood volume increase elicited by 1 nmol/kg substance P was strongly blocked (P < 0.05) by prior injection of 1 mg/kg FK888. However, the depressor effect of 1 nmol/kg substance P (-24 +/- 4 mm Hg at 30 s, P < 0.01) was partially inhibited (P < 0....Continue Reading

References

Oct 2, 2002·Clinical Endocrinology·N M Page
Oct 15, 2014·The Journal of Comparative Neurology·Paolo BarbaresiSanto Gratteri
Jan 24, 2003·Expert Opinion on Therapeutic Targets·N M PageP J Lowry
May 15, 2003·The Journal of Comparative Neurology·Samantha E GillardAnn E Kingston

Citations

Jul 1, 1978·Stroke; a Journal of Cerebral Circulation·M TomitaM Yamamoto
Jul 1, 1979·Experimental Neurology·M TomitaK Tanaka
Dec 1, 1978·Acta Physiologica Scandinavica·H SamnegrdC Björklund
Feb 1, 1975·Acta Physiologica Scandinavica·D Hallberg, B Pernow
Nov 1, 1992·British Journal of Pharmacology·T FujiiM Matsuo
Jul 1, 1992·Trends in Pharmacological Sciences·K J Watling
Sep 1, 1992·Journal of the Neurological Sciences·M KobariH Takeda
Mar 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R MacfarlaneH A Kontos
Mar 1, 1987·British Journal of Pharmacology·L Edvinsson, I Jansen
Oct 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M TomitaI Gerdsen
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J McCullochL Edvinsson
Jan 1, 1993·British Journal of Pharmacology·D T BeattieW Feniuk
Jul 1, 1993·Stroke; a Journal of Cerebral Circulation·W I RosenblumG H Nelson
Jan 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M KobariH Takeda
Jan 1, 1995·Journal of Cardiovascular Pharmacology·M TomitaM Yokoyama

Related Concepts

TAC1
Ethanol
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Adrenal Cortex Diseases
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Intravenous Injections
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Brain
N(2)-(4-hydroxy-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl)-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide

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