Intravenous administration of deaggregated mouse thyroglobulin suppresses induction of experimental autoimmune thyroiditis and expression of both Th1 and Th2 cytokines

International Immunology
H Tang, H Braley-Mullen

Abstract

Experimental autoimmune thyroiditis (EAT) can be induced by transfer of mouse thyroglobulin (MTg) and lipopolysaccharide (LPS)-immunized, MTg-activated spleen cells into syngeneic recipients. Recipients of MTg-activated T cells develop lymphocytic EAT, whereas recipients of cells activated by MTg and anti-IL-2R antibody develop a more severe and histologically distinct granulomatous form of EAT. Intravenous administration of deaggregated MTg (dMTg) 7 days before and 5 days after the first immunization of donor mice with MTg/LPS suppresses the induction of both forms of EAT. Thyroid infiltration is significantly decreased in recipients of effector cells from tolerant donors. MTg-specific T cell proliferation is partially suppressed in tolerant mice. Both IgG1 and IgG2a subclasses of anti-MTg autoantibodies are markedly inhibited in both tolerant donor mice and in recipients of tolerant spleen cells. Expression of T cell cytokine gene transcripts (IL-2, IFN gamma, IL-4, IL-10, tumor necrosis factor-alpha and transforming growth factor-beta) are all decreased in spleen cells of donor mice given dMTg. CD8+ T cells were not required for expression of tolerance since depletion of CD8+ T cells in vivo before tolerance induction or in ...Continue Reading

Citations

Sep 23, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Yongzhong WeiHelen Braley-Mullen
Dec 19, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·W FondalH Braley-Mullen
Jul 20, 2010·Experimental Neurology·Jian Rong ShengMatthew N Meriggioli
Feb 9, 1999·The Journal of Allergy and Clinical Immunology·R S Kalish, P W Askenase
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shiguang YuHelen Braley-Mullen
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H Braley-MullenS Yu
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shiguang YuHelen Braley-Mullen
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gabriela RiemekastenFalk Hiepe

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Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.