Intravenous administration of human mesenchymal stem cells after noise- or drug-induced hearing loss in rats

Acta Oto-laryngologica
Byung Yoon ChoiSeung Ha Oh

Abstract

Systemic application of human mesenchymal stem cells (hMSCs) may be another effective tool for stem cell supply to the inner ear. Most researchers have used local application to provide the inner ear with stem cells. In spite of their efficacy, these methods can potentially cause irreversible damage to the inner ear. A homing phenomenon of systemically administered MSCs to the ischemic myocardium and brain was recently reported. Moreover, hMSCs have several advantages over conventional neural or embryonic stem cells. Thus we hypothesized that intense noise or ototoxic injury to the cochlea could induce the homing of hMSCs. We harvested hMSCs from bone marrow of the iliac crest of five normal individuals. Then hMSCs at a dose of 4 × 10(6) cells were given via intravenous injection of cell suspension into rats with cochleae damaged by noise or ototoxic drugs. Histological analysis was undertaken 30 days later. Systemically delivered hMSCs were usually largely entrapped in the lungs. However, we documented the homing of some hMSCs to the cochlea with degenerated inner hair cells. The recruitment of hMSCs was limited to the spiral ganglion area only. The migration of donor cells into the cochlea was accompanied by the expression of...Continue Reading

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Citations

Jul 16, 2013·Cell Biology International·Suja Ann MathewRamesh Bhonde
Mar 30, 2017·HNO·A RoemerA Warnecke
Aug 17, 2018·Regenerative Medicine·Emily YoungKevin Gregory-Evans
Jan 12, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Shinpei KadaTakayuki Nakagawa
Feb 17, 2017·HNO·A RoemerA Warnecke
Oct 9, 2016·Stem Cell Research & Therapy·Ariane RoemerAthanasia Warnecke
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Apr 24, 2020·Molecular Biology Reports·Kevin ChorathAlvaro Moreira
Aug 17, 2020·International Journal of Molecular Sciences·Sho KanzakiKaoru Ogawa
Jul 3, 2021·Journal of Clinical Medicine·Reza KaboodkhaniFeridoun Karimi-Busheri
Sep 10, 2021·Cell Transplantation·Tetsuji Sekiya, Matthew C Holley

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