PMID: 8321427May 1, 1993

Intravenous administration of L-kynurenine to rhesus monkeys: effect on quinolinate and kynurenate levels in serum and cerebrospinal fluid

Neuropharmacology
D JauchR Schwarcz

Abstract

L-Kynurenine was administered intravenously at doses of 25, 75 and 200 mg/kg to 4 rhesus monkeys to examine the acute metabolism of kynurenine to its neuroactive products quinolinate (QUIN) and kynurenate (KYNA). Eleven serum and 6 cerebrospinal fluid (CSF) samples, the latter obtained through indwelling cisternal catheters, were collected periodically for 4 hr after the kynurenine infusion. In both serum and CSF, basal concentration of QUIN exceeded KYNA concentrations several-fold (2715 +/- 356 vs 122 +/- 16 nM in serum and 84 +/- 34 vs 6 +/- 1 nM in CSF). Following kynurenine infusion, QUIN and KYNA levels were elevated in both serum and CSF in proportion to the dose of the bioprecursor. Serum QUIN concentrations increased slowly, reaching a steady-state level of 29 microM 90 min after 200 mg/kg kynurenine. Serum KYNA levels rose more rapidly, peaking within 10 min and gradually declining thereafter (2.8 microM after 4 hr using 200 mg/kg kynurenine). In CSF, both QUIN and KYNA increased steadily, attaining plateau levels of 2.8 and 0.3 microM, respectively, 4 hr after a kynurenine dose of 200 mg/kg. Under all experimental conditions, CSF KYNA levels were substantially lower than CSF QUIN levels. These data show that in non-h...Continue Reading

References

Jan 20, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Gillian M MackayL Gail Darlington
May 8, 2013·British Journal of Pharmacology·Trevor W Stone, L Gail Darlington
Apr 20, 2005·Journal of Neurochemistry·Nicholas StoyL Gail Darlington
Jun 14, 2013·International Journal of Tryptophan Research : IJTR·Chai K LimGilles J Guillemin
Sep 21, 2013·International Journal of Tryptophan Research : IJTR·Michal P TurskiGregory F Oxenkrug

Citations

May 1, 1976·Hoppe-Seyler's Zeitschrift für physiologische Chemie·T Noguchi, R Kido
Aug 1, 1975·Hoppe-Seyler's Zeitschrift für physiologische Chemie·T NoguchiR Kido
May 11, 1992·Annals of the New York Academy of Sciences·R SchwarczR C Roberts
Jan 1, 1992·Neurology·J J Halperin, M P Heyes
May 1, 1992·The Biochemical Journal·M P HeyesS P Markey
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Mar 1, 1991·Brain Research·E OkunoR Schwarcz
May 1, 1989·Journal of Neurochemistry·Waldemar A TurskiR Schwarcz
Jul 1, 1985·Neuroscience·Trevor W Stone, J H Connick
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Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R SchwarczW O Whetsell
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Jul 26, 1985·Biochimica Et Biophysica Acta·E Okuno, R Schwarcz
Oct 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·L V Hankes, R R Brown
Jul 2, 1984·Life Sciences·R SchwarczC Köhler
Jun 1, 1981·Epilepsia·I P Lapin
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Related Concepts

Kynurenate
Kynurenine
High Pressure Liquid Chromatography Procedure
Macaca mulatta
Dose-Response Relationship, Drug
Quinolinic Acid, Strontium Salt
Intravenous Infusion Procedures

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