Intravenous administration of oral N-acetylcysteine

Critical Care Medicine
L YipK M Hurlbut

Abstract

To report the indications and adverse events associated with administration of the oral N-acetylcysteine preparation by the intravenous route. Retrospective consecutive case series analysis of 226,720 Toxic Exposure Surveillance System data sheets from a certified regional poison center during the period January 1, 1992 through December 31, 1993. A regional poison center certified by the American Association of Poison Control Centers. Seventy-six patients treated with the oral N-acetylcysteine solution by the intravenous route. None. We report the indications and adverse events associated with the intravenous administration of the oral N-acetylcysteine preparation. Four (4/76, 5.3%) patients developed adverse events attributable to N-acetylcysteine. None of these events involved hemodynamic, cardiovascular, or pulmonary effects. All reactions occurred during infusion of the initial N-acetylcysteine dose. There were three (3/76, 3.9%) deaths overall; however, they were not attributable to the intravenous administration of the oral N-acetylcysteine preparation. Intravenous administration of the oral N-acetylcysteine preparation appears to have limited adverse effects and offers another mechanism of delivery of the potentially lif...Continue Reading

References

Oct 1, 1991·Annals of Emergency Medicine·M J SmilksteinB H Rumack
Jan 1, 1989·European Journal of Clinical Pharmacology·L F PrescottA T Proudfoot
Mar 20, 1989·The Medical Journal of Australia·A H DawsonJ McEwen
Jul 28, 1984·British Medical Journal·T G MantJ C Talbot
Oct 1, 1984·Human Toxicology·D N BatemanM D Rawlins
Feb 23, 1981·Archives of Internal Medicine·L F Prescott
Sep 1, 1996·The American Journal of Emergency Medicine·T L LitovitzW Klein-Schwartz

❮ Previous
Next ❯

Citations

Oct 7, 2008·Journal of Hepato-biliary-pancreatic Surgery·Andrew McKayElijah Dixon
Feb 15, 2001·Current Gastroenterology Reports·G MarinoJ H Lewis
Sep 12, 2000·Current Gastroenterology Reports·C J McClainS Shedlofsky
Nov 30, 2000·Current Treatment Options in Gastroenterology·S Chitturi, G C Farrell
Dec 17, 2010·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Omid Mehrpour, Mahdi Ballali-Mood
Jul 19, 2008·The New England Journal of Medicine·Kennon J Heard
Jan 16, 2007·Antimicrobial Agents and Chemotherapy·Saima AslamRabih O Darouiche
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·Jason ChuNicholas S Hill
Oct 2, 2014·European Journal of Clinical Pharmacology·Y LeangS L Greene
Mar 13, 2009·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·E A Sandilands, D N Bateman
Jun 8, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Vikhyat S BebartaMohammed Al-Helial
Nov 26, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Anselm Wong, Andis Graudins
Feb 11, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Barry H Rumack, D Nicholas Bateman
Feb 15, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·P A ChykaM I Herman
Jul 11, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·E Kozer, G Koren
Mar 12, 2003·Chest·Babak MokhlesiThomas C Corbridge
Sep 25, 2012·Critical Care Clinics·Michael J Hodgman, Alexander R Garrard
Oct 22, 1998·Critical Care Medicine·M Tenenbein
Jan 28, 2009·Biomaterials·Yunus E KurtogluRangaramanujam M Kannan
Nov 22, 2008·The Journal of Emergency Medicine·Allyson J WhyteDevin Sokolowski
Jul 9, 2008·The American Journal of Emergency Medicine·Christopher CrowellShad H Deering
Aug 29, 2007·Clinics in Liver Disease·Anne M Larson
Mar 29, 2006·Clinics in Laboratory Medicine·Adam K RowdenMark A Kirk
Aug 19, 2003·Pharmacotherapy·Todd Kociancic, Michael D Reed
Jan 27, 2009·The Mount Sinai Journal of Medicine, New York·Hui-Hui TanPaul Martin
Aug 7, 2010·Transplantation Reviews·Ryan M FordRam M Subramanian
Mar 30, 2005·Annals of Emergency Medicine·Laurie Prescott
Jan 27, 2005·Annals of Emergency Medicine·Eric J LavonasMary A Wittler
Jun 13, 1998·Annals of Emergency Medicine·B Bailey, M A McGuigan
Oct 18, 2005·The Medical Clinics of North America·Adam K RowdenMark A Kirk
Jan 9, 2004·Clinics in Chest Medicine·Babak Mokhlesi, Thomas Corbridge
Feb 15, 2001·Intensive & Critical Care Nursing : the Official Journal of the British Association of Critical Care Nurses·G SeftonJ Noyes
Apr 22, 2015·Photodiagnosis and Photodynamic Therapy·Nasim KashefGholamreza Esmaeeli Djavid
Mar 7, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Anna K ShovellerRonald O Ball
Sep 27, 2005·Toxicological Reviews·Colleen M Culley, Edward P Krenzelok
Jan 6, 2011·The Annals of Pharmacotherapy·Spencer M AndersonRamesh V Patel
Dec 1, 2012·Therapeutic Advances in Drug Safety·W Stephen Waring
Apr 1, 2005·Current Opinion in Pediatrics·Laurie Marzullo
Dec 15, 2005·Southern Medical Journal·Jason M WilkesJorge L Herrera
Feb 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Claudia Zwingmann, Marc Bilodeau

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.