Intravenous administration of the conditionally replicative adenovirus Ad5-Delta24RGD induces regression of osteosarcoma lung metastases.

Molecular Cancer
Harm C A GraatPaul I J M Wuisman

Abstract

Metastatic osteosarcoma (OS) has a very poor prognosis. New treatments are therefore wanted. The conditionally replicative adenovirus Ad5-Delta24RGD has shown promising anti-tumor effects on local cancers, including OS. The purpose of this study was to determine whether intravenous administration of Ad5-Delta24RGD could suppress growth of human OS lung metastases. Mice bearing SaOs-lm7 OS lung metastases were treated with Ad5-Delta24RGD at weeks 1, 2 and 3 or weeks 5, 6 and 7 after tumor cell injection. Virus treatment at weeks 1-3 did not cause a statistically significant effect on lung weight and total body weight. However, the number of macroscopic lung tumor nodules was reduced from a median of >158 in PBS-treated control mice to 58 in Ad5-Delta24RGD-treated mice (p = 0.15). Moreover, mice treated at weeks 5-7 showed a significantly reduced lung weight (decrease of tumor mass, p < 0.05), a significantly increased body weight gain (decrease of disease symptoms, p < 0.005) and a reduced number of macroscopic lung tumor nodules (median 60 versus > 149, p = 0.12) compared to PBS treated control animals. Adenovirus hexon expression was detected in lung tumor nodules at sacrifice three weeks after the last intravenous adenovirus ...Continue Reading

Citations

Apr 9, 2010·Future Oncology·Pooja Hingorani, Edward A Kolb
Jul 19, 2011·Journal of Pediatric Surgery·Phillip A LetourneauAndrea A Hayes-Jordan
Oct 1, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Lin FangChang-Qing Su
Feb 10, 2012·Expert Review of Anticancer Therapy·Christina K LettieriE Anders Kolb
Apr 17, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Naiara Martinez-VelezMarta M Alonso
Aug 28, 2021·Cancers·Adrian Emilian BădilăAdrian Radu Rădulescu

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