Intravenous amiodarone in acute anterior myocardial infarction: a controlled study

Cardiovascular Drugs and Therapy
R GrecoN Mininni

Abstract

A randomized, single-blind controlled study intended to assess the potential benefits of intravenous amiodarone in anterior myocardial infarction is presented. Three hundred nineteen patients entered the study, 159 received amiodarone infusion, and 160 received glucose-insulin-potassium (GIK) infusion. Basal characteristics were similar in the two experimental groups, who were randomized on a consecutive basis. Exclusion criteria were shock or pulmonary edema, hypotension, inferoposterior infarction, bradycardia, antrioventricular block, severe diabetes, and other major diseases. Patients aged 27 to 70 years, with a Q-wave anterior infarction, initiated 12-40 hours earlier at the time of admission, entered the trial. Other entry criteria were heart rate higher than 80 beats/min and systolic blood pressure higher than 100 mmHg. Amiodarone was administered in saline infusion 10-20 mg/kg, within 4 to 10 hours, through a central vein. GIK infusion consisted of 150-300 g of glucose, 25-50 IU of insulin, and 80-120 mEq of KCl in 1000 cc of water at a rate of 1.5-2.0 ml/g/hour. Both groups received digitalis, nitrates, sedatives, and diuretics as needed. Although individually the major endpoints of death, reinfarction, and sustained s...Continue Reading

References

Nov 1, 1987·The American Journal of Cardiology·B E HockingsH A Hajar
Jul 8, 1972·British Medical Journal·S W WebbJ F Pantridge
Sep 22, 1983·The American Journal of Cardiology·P J Block, R A Winkle
Sep 1, 1980·Circulation·A LottoM R Baldini

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