Intravenous amiodarone in treatment of recent-onset atrial fibrillation: results of a randomized, controlled study

Journal of the American College of Cardiology
E GalveJ Soler-Soler

Abstract

This study was designed to determine the efficacy of intravenous amiodarone in the management of recent-onset atrial fibrillation. The optimal approach for acute atrial fibrillation has not been established. Amiodarone is a unique antiarrhythmic agent with activity in both supraventricular and ventricular tachyarrhythmias, but its value for the restoration of sinus rhythm in patients with recent-onset atrial fibrillation has not been demonstrated. Sample size was calculated to detect a 25% increase in reversion rate with amiodarone with a statistical power of 80%. One hundred consecutive patients with recent-onset (<1 week) atrial fibrillation and not taking antiarrhythmic agents were randomized to receive either intravenous amiodarone, 5 mg/kg body weight in 30 min followed by 1,200 mg over 24 h, or an identical amount of saline. Both groups received intravenous digoxin, 0.5 mg initially, followed by 0.25 mg at 2 h and 0.25 mg every 6 h thereafter, to complete 24 h while the ventricular rate was >100 beats/min. Amiodarone and digoxin blood levels were determined. Both groups were homogeneous regarding underlying heart disease, time from onset to treatment, initial ventricular rate and left atrial size. By the end of the 24-h t...Continue Reading

References

Apr 1, 1992·International Journal of Cardiology·G Vietti-RamusR Latini
Jan 15, 1991·The American Journal of Cardiology·K D DonovanG M Clarke
Jan 30, 1987·The American Journal of Cardiology·B N Singh, K Nademanee
Mar 1, 1987·European Heart Journal·P CoumelB Escoubet
Apr 1, 1983·European Journal of Clinical Investigation·N M DebbasP Puech
Jan 1, 1994·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A D CochraneB B Davis

❮ Previous
Next ❯

Citations

Jun 21, 2006·Herzschrittmachertherapie & Elektrophysiologie·M Linhart, T Lewalter
Nov 8, 2005·Annals of Emergency Medicine·Carmen del ArcoUNKNOWN Investigators in the Spanish Atrial Fibrillation in Emergency Medicine Study Group (GEFAUR)
Aug 6, 2000·Current Problems in Cardiology·J SraM Akhtar
May 28, 2003·International Journal of Cardiology·Ijaz A KhanRamesh M Gowda
Jan 22, 2003·Journal of the American College of Cardiology·Philippe ChevalierPaul Touboul
Mar 21, 1998·Journal of the American College of Cardiology·P G DaniasW J Manning
Aug 10, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M S WeinfeldL W Stevenson
Dec 2, 2010·Nature Reviews. Drug Discovery·Dobromir DobrevPeter Kirkpatrick
Jan 10, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Ron PistersUNKNOWN Euro Heart Survey Investigators
Mar 22, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Mariam B ChoudharyPyotr G Platonov
Nov 6, 2002·The American Journal of Geriatric Cardiology·Mark Dayer, Suzanna M C Hardman
Feb 6, 2002·Congestive Heart Failure·M S Matalka, P C Deedwania
May 19, 1998·Pacing and Clinical Electrophysiology : PACE·C CosteasJ A Reiffel
Nov 24, 1998·Pacing and Clinical Electrophysiology : PACE·G BorianiB Magnani
Nov 18, 1997·Journal of Cardiovascular Electrophysiology·L I Ganz, E M Antman
Jan 29, 2005·BMJ : British Medical Journal·M Bilal IqbalMarcus Flather
Feb 21, 2002·Journal of Cardiothoracic and Vascular Anesthesia·Arvind Rajagopal, Davy C H Cheng
Dec 3, 2014·Cardiology Clinics·Muhammad Rizwan SardarPeter R Kowey
Oct 22, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
Jan 17, 2013·Postgraduate Medicine·Bharath Rajagopalan, Anne B Curtis
Feb 14, 2012·Expert Opinion on Drug Safety·Pasquale SantangeliAndrea Natale
Oct 17, 2012·Scandinavian Cardiovascular Journal. Supplement·Magnus Heldal, Dan Atar
Dec 24, 1997·Cardiology Clinics·F A Masoudi, N Goldschlager
May 5, 2012·Heart, Lung & Circulation·Kugathasan Nadarasa, Michael J A Williams
Sep 19, 2007·The Canadian Journal of Cardiology·Valerio ZacàFrancesco Guerrini
Feb 19, 2011·The Canadian Journal of Cardiology·Anne M GillisUNKNOWN CCS Atrial Fibrillation Guidelines Committee
Sep 10, 2010·The American Journal of Emergency Medicine·Michael M HirschlSebastian Globits
Mar 26, 2010·Lancet·Dobromir Dobrev, Stanley Nattel
Mar 13, 2016·Heart Failure Clinics·Muhammad Rizwan SardarPeter R Kowey
Sep 4, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Nora GoldschlagerUNKNOWN Practice Guidelines Sub-committee, North American Society of Pacing and Electrophysiology (HRS)

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